136964-14-2

Upstream product

• 676-83-5 methyldichlorophosphane 
• 1524-15-8 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-1-one 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 188429-64-3 2,2,2-trifluoro-N,N,N',N'-tetramethylethane-1,1-diamine 
• 325704-95-8 4,4,4-trifluoro-3-N,N-dimethylamino-1-phenyl-1-butanone 
• 98-86-2 acetophenone 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 123-75-1 pyrrolidine 
• 614-20-0 3-oxo-3-phenylpropionic acid 
• 1514-82-5 2-bromo-3,3,3-trifluoropropene 
• 100-52-7 benzaldehyde 
• 149846-93-5 1-phenyl-4,4,4-trifluorobut-2-yn-1-ol 
• 1131-80-2 (E)-3-(N,N-dimethylamino)-1-phenyl-2-propen-1-one 

Downstream Products

• 3108-34-7 (E)-4,4,4-trifluoro-1-phenyl-2-buten-1-one 
• 1020171-83-8 (R)-4,4,4-trifluoro-1,3-diphenylbutan-1-one 
• 1453495-97-0 (3S,4R)-3-(2-(benzyloxy)ethyl)-6-phenyl-4-(trifluoromethyl)-3,4-dihydro-2H-pyran-2-one 
• 1453495-93-6 (3S,4R)-3-butyl-6-phenyl-4-(trifluoromethyl)-3,4-dihydro-2H-pyran-2-one 
• 1453495-96-9 (3S,4R)-3-methyl-6-phenyl-4-(trifluoromethyl)-3,4-dihydro-2H-pyran-2-one 
• 221195-90-0 3-benzoyl-2-trifluoromethylpropionitrile 
• 134391-61-0 (E)-1,1,1,5,5,5-hexafluoro-2-phenylpent-3-en-2-ol 

Relevant academic research and scientific papers

STEREOISOMERISM OF β-POLYFLUOROALKYL-α,β-ENONES

β-Polyfluoroalkyl-α,β-enones formed in the E,Z form are converted by the action of atmospheric oxygen into a 93:7 mixture of E,Z and Z,E isomers in the dark and 60:40 mixture of these isomers in the light.The Z isomer of 1-phenyl-4,4,4-trifluoro-2-buten-1-one was isolated preparatively for the first time and its E conforamation relative to the C-C bond was established.The Z,E isomer spontaneously transforms into the indicated equilibrium mixtures.

Highly Enantioselective [3 + 2] Annulation of 3-Butynoates with β-Trifluoromethyl Enones Promoted by an Amine-Phosphine Binary Catalytic System

We report a highly enantioselective [3 + 2] annulation between 3-butynoates and β-trifluoromethyl enones, furnishing trifluoromethylated cyclopentenes with three contiguous stereogenic centers in good yields, high diastereoselectivities, and excellent enantioselectivities. A unique catalytic system consisting of a simple amine and a chiral phosphine was devised, and the synergistic play of Lewis basic amine and phosphine was crucial for alkyne isomerization and subsequent cyclization. The protocol disclosed herein allows facile activation of 3-butynoates in phosphine-mediated asymmetric transformations.

Oxidation of 4-Aryl-1,1,1-trifluorobut-2-en-2-yl Trifluoro?-methanesulfonates by 4-Picoline-N-Oxide: A Novel Approach to β-Trifluoromethyl-α,β-enones

An efficient approach to β-trifluoromethyl-α,β-enones via oxidation of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates is described. The reaction proceeds smoothly under mild and metal?-free conditions and tolerates a wide range of functional groups. Various β-trifluoromethyl-α,β-enones were obtained in moderate to good yields.

Preparation method of (E)-1-aryl-4, 4, 4-trifluorobutyl-2-ene-1-one compound

The invention discloses a preparation method of an (E)-1-aryl-4, 4, 4-trifluorobutyl-2-ene-1-one compound, and belongs to the field of compound preparation. The (E)-1-aryl-4, 4, 4-trifluorobutyl-2-ene-1-one compound is prepared by taking a compound shown

Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones

A practical Lewis acid-catalyzed Meyer-Schuster rearrangement of fluoroalkylated propargylic alcohols, leading to a series of β-fluoroalkyl-α,β-enones, is developed. The methodology reported herein features moderate to high yields and high stereoselectivi

Rh(III)-Catalyzed [3 + 2] Annulation via C-H Activation: Direct Access to Trifluoromethyl-Substituted Indenamines and Aminoindanes

The rhodium(III)-catalyzed direct C-H addition and annulation of benzimidates and aldimines with β-(trifluoromethyl)-α,β-unsaturated ketones is described. This protocol provides the facile and efficient formation of various trifluoromethyl-containing inde

Chiral Hydroxytetraphenylene-Catalyzed Asymmetric Conjugate Addition of Boronic Acids to Enones

(S)-2,15-Br2-DHTP-catalyzed asymmetric conjugate addition of boronic acids to β-trifluoromethyl α,β-unsaturated ketones and enones was studied. The reaction afforded the corresponding Michael addition products in moderate to high yields with excellent enantioselectivities (up to 99:1 er). This catalytic system features mild reaction conditions, high efficiency, and tolerance to heteroarylboronic acids.

A Remarkable Influence of a Trifluoromethyl Group on the Reactions of β-Mercaptoalcohols with Fluorinated α-Bromoenones

Isomeric fluorinated α-bromoenones react with dinucleophilic β-mercaptoalcohols in CH2Cl2 at room temperature in the presence of Et3N in a multistep process. Depending on the position of the CF3 group, different O,S-heterocycles or non-cyclic products were obtained. With 3-bromo-1,1,1-trifluorobut-3-en-2-ones derivatives of 1,4-oxathianes were formed, but isomeric 2-bromo-4,4,4-trifluorobut-2-en-1-ones yielded 1,3-oxathiolanes or non-cyclic sulfides. The thia-Michael addition is proposed as the initial step of the reaction, and the final heterocyclization is governed by the location of the CF3 group.

Rhodium(III)-catalyzed sp2 C-H bond addition to CF3-substituted unsaturated ketones

Rhodium(iii)-catalyzed conjugate addition of aromatic and olefinic C-H bonds to CF3-substituted unsaturated ketones was efficiently achieved. Both arene and olefin substrates bearing a chelate assisted-directing group were coupled with a variet

Copper-catalyzed one-pot denitrogenative-dehydrogenative-decarboxylative coupling of β-ketoacids with trifluorodiazoethane: Facile access to trifluoromethylated aldol products

A novel copper-catalyzed one-pot cross-coupling of β-ketoacids with in situ generated trifluorodiazoethane has been developed. This reaction provides a direct and efficient method, in which one C-C bond and one C-O bond were formed in a carbenoid center with concomitant denitrogenation-dehydrogenation- decarboxylation, to afford trifluoromethylated aldol products. In several preliminary experiments, good to high enantioselectivities were also obtained.