13719-31-8

Upstream product

• 4091-26-3 β-styrenesulfonyl chloride 
• 108-95-2 phenol 
• 405-18-5 trans-2-phenylethene-1-sulfonyl fluoride 
• 18052-27-2 tert-butyldimethyl(phenoxy)silane 
• 100-42-5 styrene 
• 52147-97-4 trans 2-phenylethenesulfonyl chloride 
• 109880-31-1 (E)-2-Phenyl-ethenesulfonic acid 4-benzyloxy-phenyl ester 

Downstream Products

• 140455-05-6 2-phenyl-3,3-diethoxycarbonylpropane-1-sulfonic acid phenyl ester 
• 140455-04-5 2-phenyl-3,3-dicyanopropane-1-sulfonic acid phenyl ester 
• 112614-96-7 4-phenyl-2H-[1,2,3]triazole 
• 140455-07-8 2-phenyl-3-cyano-3-ethoxycarbonylpropane-1-sulfonic acid phenyl ester 
• 153900-18-6 3-nitro-2-phenylpropane-1-sulfonic acid phenyl ester 
• 1174908-76-9 2-phenylethane-1,2-dibromo-1-phenylsulfonate ester 
• 1380035-38-0 C₂₁H₂₀O₃S 
• 948-55-0 1-phenyl-1-p-tolyl-ethylene 
• 320393-21-3 3-amino-2-phenylpropane-1-sulfonic acid phenyl ester 
• 320393-23-5 4-phenylsultam 

Relevant academic research and scientific papers

Converting (E)-(Hetero)arylethanesulfonyl Fluorides to (Z)-(Hetero)arylethanesulfonyl Fluorides Under Light Irradiation

The construction of (Z)-(hetero)arylethenesulfonyl fluorides was achieved utilizing Iridium photoredox catalysis under UV-light irradiation. This protocol provided a diverse range of (Z)-(hetero)arylethenesulfonyl fluorides in moderate to good yields under mild conditions without external additives. The late-stage transformation of the (Z)-(hetero)arylethenesulfonyl fluorides comparing with their E-configuration counterparts was also studied.

Antioxidant, Anti-inflammatory, and Neuroprotective Effects of Novel Vinyl Sulfonate Compounds as Nrf2 Activator

The main pathway responsible for cellular regulation against oxidative stress is nuclear factor E2-related factor-2 (Nrf2) signaling. We previously synthesized and reported a novel vinyl sulfone (1) as an Nrf2 activator with therapeutic potential for Parkinson's disease (PD). In this study, we changed the vinyl sulfone to vinyl sulfonamide or vinyl sulfonate to improve Nrf2 activating efficacy. We observed that the introduction of vinyl sulfonamide led to a reduction of the effects on Nrf2 activation, whereas vinyl sulfonate compounds exhibited superior activity compared to the vinyl sulfone compounds. Among the vinyl sulfonates, 3c exhibited 6.9- and 83.5-fold higher effects on Nrf2 activation than the corresponding vinyl sulfone (1) and vinyl sulfonamide (2c), respectively. Compound 3c was confirmed to induce expression of the Nrf2-dependent antioxidant enzymes at the protein level in cells. In addition, 3c mitigated PD-associated behavioral deficits by protecting DAergic neurons in the MPTP-induced mouse model of PD.