1374639-83-4

Upstream product

• 504-29-0 2-aminopyridine 
• 24721-26-4 4-chlorochalcone 
• 104-88-1 4-chlorobenzaldehyde 
• 98-86-2 acetophenone 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 
• 122-01-0 4-chloro-benzoyl chloride 
• 70-11-1 α-bromoacetophenone 
• 14547-82-1 4-chloro-N-(pyridine-2-yl)benzamide 
• 110-89-4 piperidine 

Relevant academic research and scientific papers

One-pot, three component tandem reaction of 2-aminopyridines, acetophenones and aldehydes: Synthesis of 3-aroylimidazo[1,2-a]pyridines

A facile synthesis of 3-aroylimidazo[1,2-a]pyridine derivatives has been achieved through the one-pot, three-component tandem reaction of acetophenones, arylaldehydes and 2-aminopyridines in the presence of a catalytic amount of copper(ii) chloride and air as the sole oxidant. The developed one-pot method is atom-economical and utilizes readily available precursors to offer highly functionalized N-fused imidazoles in moderate to good yields (26-82%). The presented tandem process is expected to proceed via crossed aldol condensation, Michael addition, copper catalyzed oxidative cyclization and subsequent aromatization.

Superparamagnetic nanoparticle-catalyzed coupling of 2-amino pyridines/pyrimidines with trans-chalcones

An aerobic coupling of 2-aminopyrimidines or 2-aminopyridines with trans-chalcones to afford aroylimidazo[1,2-a]pyrimidines and aroylimidazo[1,2-a]pyridines is reported. Reactions proceed in the presence of CuFe2O4 superparamagnetic

Synthetic method of imidazo[1,2-a]pyridine

The invention discloses a novel method for synthesizing imidazo[1,2-a]pyridine. According to the method, imidazo[1,2-a]pyridine is synthesized from 2-aminopyridine and chalcone through oxidization cyclization by taking 1,2-dichloroethane as a solvent and iodine as a catalyst. The method has the advantages that the operation is simple, the raw materials are easily available, reaction conditions are mild, the yield is relatively high, and the practicability is strong. The method is applicable to industrial production.

Copper supported on H+-modified manganese oxide octahedral molecular sieves (Cu/H-OMS-2) as a heterogeneous biomimetic catalyst for the synthesis of imidazo[1,2-a]-N-heterocycles

Copper supported on acid-modified manganese oxide octahedral molecular sieves (Cu/H-OMS-2) was prepared and found to be a versatile catalyst for the oxidative synthesis of 3-aroylimidazopyridines with a broad substrate scope. Cu/H-OMS-2 that was character

Copper(II)-catalyzed aerobic oxidative coupling between chalcone and 2-aminopyridine via C-H amination: An expedient synthesis of 3-aroylimidazo[1,2-a]pyridines

A simple and efficient protocol has been developed for the synthesis of 3-aroylimidazopyridines via copper(II) acetate-catalyzed aerobic oxidative amination. A library of 3-aroylimidazopyridines was synthesized from readily accessible chalcones and 2-aminopyridines with high yields and regioselectivity. The reaction proceeds through a tandem Michael addition followed by an intramolecular oxidative amination. The successful application of this methodology for a gram-scale reaction indicates its potential for bulk synthesis.

Toward versatile methods leading to highly functionalized imidazo[1,2-a]pyridines

A convenient and general method of preparation of polyfunctionalized imidazo[1,2-a]pyridines is reported. This methodology involves activation of secondary amides leading to the formation of the corresponding amidines 9. Different activating reagents have