1392102-37-2

Upstream product

• 589-21-9 (4-bromophenyl)hydrazine 
• 618-31-5 benzylidene dibromide 
• 1246471-94-2 5-bromo-2-(5-bromo-1H-indol-2-yl)phenol 
• 1585969-16-9 (6S,12aR)-3,10-dibromo-6-phenyl-12,12a-dihydro-6H-benzo-[5,6][1,3]oxazino[3,4-a]indole 
• 1585969-24-9 (R)-2-(1-amino-2-(2,5-dibromophenyl)ethyl)-5-bromophenol 
• 1585969-22-7 5-bromo-2-(2-(2,5-dibromophenyl)-1-iminoethyl)phenol 
• 1403991-85-4 1-(4-bromo-2-hydroxyphenyl)-2-(2,5-dibromophenyl)ethanone 
• 1585969-17-0 (R)-5-bromo-2-(5-bromoindolin-2-yl)phenol 
• 1369594-56-8 3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole 
• 1369594-43-3 C₁₄H₁₂Br₂N₂O 
• 30186-18-6 4'-bromo-2'-hydroxyacetophenone 

Relevant academic research and scientific papers

A Mild Cu(I)-Catalyzed Oxidative Aromatization of Indolines to Indoles

A novel method for the oxidation of indolines to indoles is described. The method uses a Cu(I) catalyst and an organic percarbonate as the stoichiometric oxidant. The procedure was successfully applied at 0.5 kg scale in the production of a key intermediate in the synthesis of Elbasvir, which is a novel therapy for the treatment of hepatitis C virus infection.

Asymmetric synthesis of cyclic indole aminals via 1,3-stereoinduction

A general and efficient asymmetric synthesis of cyclic indoline aminals was developed with a high level of 1,3-stereoinduction through a dynamic crystallization-driven condensation. Dehydrogenation of the indoline aminals with potassium permanganate produced the corresponding cyclic indole aminals in high yields and excellent enantioselectivities. This general methodology was successfully applied to the synthesis of a wide variety of chiral cyclic indoline aminals and indole aminals with aromatic and aliphatic functional groups.

Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors

A matched and mixed capping SAR study was conducted on the tetracyclic indole class of HCV NS5A inhibitors to examine the influence of modifications of this region on the overall HCV virologic resistance profiles.

TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION

Tetracyclic indole derivatives of formula (I), pharmaceutically acceptable salts and the pharmaceutical compositions thereof are provided, wherein A, A', G, R1, R15, U, V, V, W, W, X, X', Y, Y' are as defined in the invention. Use of these derivatives for treating hepatitis C virus (HCV) infection is also provided.