Journal of Organic Chemistry p. 10009 - 10015 (2016)
Update date:2022-07-30
Topics:
Peng, Feng
McLaughlin, Mark
Liu, Yizhou
Mangion, Ian
Tschaen, David M.
Xu, Yingju
A novel method for the oxidation of indolines to indoles is described. The method uses a Cu(I) catalyst and an organic percarbonate as the stoichiometric oxidant. The procedure was successfully applied at 0.5 kg scale in the production of a key intermediate in the synthesis of Elbasvir, which is a novel therapy for the treatment of hepatitis C virus infection.
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