14167-12-5

Usage

Uses

Used in Catalyst Applications:
N,N'-DISALICYLAL-ETHYLENEDIAMINE IRON(II) is used as a catalyst in the chemical industry for its ability to facilitate various organic reactions. Its role in catalyzing the oxidation of organic compounds and the synthesis of heterocyclic compounds is particularly noteworthy, contributing to the efficiency and selectivity of these processes.
Used in Polymer Preparation:
In the field of polymer chemistry, N,N'-DISALICYLAL-ETHYLENEDIAMINE IRON(II) is utilized in the preparation of polymers, where its catalytic properties aid in the formation of polymer chains with desired characteristics.
Used in Analytical Chemistry:
N,N'-DISALICYLAL-ETHYLENEDIAMINE IRON(II) also serves as a reagent in analytical chemistry, where it helps in the identification and quantification of various chemical species, thereby playing a crucial role in research and quality control processes.

InChI:InChI=1/C16H16N2O2.Fe/c19-15-7-3-1-5-13(15)11-17-9-10-18-12-14-6-2-4-8-16(14)20;/h1-8,11-12,19-20H,9-10H2;/q;+2/p-2/b17-11+,18-12+;

Upstream product

• 14167-20-5 nickel(II) salen 
• 1834-30-6 iron(II) acetate 
• 1091611-04-9 bis(N-(n-butyl)salicylaldiminato)nickel(II) 
• 15379-71-2 bis(salicylaldehyde)-nickel(II)-dihydrate 
• 90-02-8 salicylaldehyde 
• 97-51-8 5-Nitrosalicylaldehyde 
• 100-02-7 4-nitro-phenol 
• 402826-43-1 tert-butyl (3-formyl-4-hydroxyphenyl)carbamate 
• 24590-01-0 acetyloxy(2-acetyloxy-5-nitrophenyl)methyl acetate 
• 784193-20-0 acetyloxy(2-acetyloxy-5-aminophenyl)methyl acetate 
• 1166842-07-4 C₂₆H₃₄N₄O₆ 
• 94-93-9 N,N'-ethylenebis(salicylideneimine) 
• 7439-89-6 iron 
• 94-93-9 N,N'-ethylenebis(2-hydroxybenzylideneimine) 

Downstream Products

• 114324-84-4 (Et₄N){Fe(salen)(PhS)} 
• 114324-88-8 Na{Fe(salen)(2,4,6-i-Pr₃C₆H₂S)} 
• 114324-87-7 Na{Fe(salen)(2,6-Me₂C₆H₃S)} 
• 114324-99-1 Na{Fe(salen)(p-MeC₆H₄O)} 
• 113432-07-8 (μ-p-tolylimido)bis{N,N'-ethane-1,2-diylbis(salicylaldiminato)iron(III)} 
• 115186-42-0 (μ-phenylimido)bis{N,N'-ethane-1,2-diylbis(salicylaldiminato)iron(III)} 
• 18601-34-8 (μ-oxo)bis[(1,2-ethanediamino-N,N'-bis(salicylidene))iron(III)] 
• 1227476-15-4 Azobenzene 
• 495-48-7 azoxybenzene 
• 143145-25-9 Mn⁽²⁺⁾*C₆H₃(OCH₃)OCHN(CH₂)3NCHC₆H₃(OCH₃)O^(2-) = (C₆H₃CH₃O(O)CHN(CH₂)3NCHC₆H₃CH₃O(O))Mn 
• 23324-43-8 (CH₂NCHC₆H₃(O)Cl)2^(2-)*Mn⁽²⁺⁾ 
• 90584-08-0 (meso-tetraphenylporphyrinato)bis(tetrahydrofuran)ruthenium(II) 

Relevant academic research and scientific papers

A Straightforward Electrochemical Approach to Imine- and Amine-bisphenolate Metal Complexes with Facile Control Over Metal Oxidation State

Synthetic methods to prepare organometallic and coordination compounds such as Schiff-base complexes are diverse, with the route chosen being dependent upon many factors such as metal–ligand combination and metal oxidation state. In this work we have shown that electrochemical methodology can be employed to synthesize a variety of metal–salen/salan complexes which comprise diverse metal–ligand combinations and oxidation states. Broad application has been demonstrated through the preparation of 34 complexes under mild and ambient conditions. Unprecedented control over metal oxidation state (MII/III/IVwhere M=Fe, Mn) is presented by simple modification of reaction conditions. Along this route, a general protocol-switch is described which allows access to analytically pure FeII/III–salen complexes. Tuning electrochemical potential, selective metalation of a Mn/Ni alloy is also presented which exclusively delivers MnII/IV–salen complexes in high yield.

Method for continuously synthesizing epsilon-caprolactone

The invention discloses a method for continuously synthesizing epsilon-caprolactone, which is characterized in that cyclohexanone is used as a raw material, hydrogen peroxide is used as an oxidant, and the epsilon-caprolactone is prepared by continuous oxidation reaction in a microchannel reactor under the action of a catalyst. The method is simple and easy to implement, compared with a traditional peroxycarboxylic acid process, the safety is remarkably improved, and the method has important social benefits and economic benefits.

Design, synthesis and biological evaluation of cobalt(II)-Schiff base complexes as ATP-noncompetitive MEK1 inhibitors

In this report, we designed and synthesized a series of cobalt(II)-Schiff base complexes (CoSBC) with competent MEK1 (mitogen-activated protein kinase kinase?1) inhibitory activity. Based on our previous report, the CoSBC exhibited high binding affinity with MEK1 protein. To further explore metal complexes as MEK1 inhibitors, a series of transition metals and ligands were employed to build a library of various metal Schiff base complexes. The MEK inhibition assays revealed that only CoSBC exhibited obvious inhibitory activity, complex 2b showed the best inhibition both in BRaf (B-rapidly accelerated fibrosarcoma)/MEK1 and MEK1/ERK2 (extracellular signal-regulated kinases-2) cascading (IC50 is 1.988 ± 0.14 μM and 1.589 ± 0.054 μM respectively). In addition, homogeneous time-resolved fluorescence test method was used to prove that CoSBC as ATP-noncompetitive MEK1 inhibitor. MEK kinase selectivity assay indicated that CoSBC can selectively inhibit MEK1/2 kinases rather than other MAPKs (mitogen-activated protein kinases) family kinases. Moreover, the interaction mode of 2b with MEK1 protein has been demonstrated by computer aided drug design.

Air Oxidation of Benzoin Catalyzed by Metal-Salen Complexes

Metal-Salen (M = Fe, Co, Ni, Cu, Zn) complexes were synthesized to catalyze the oxidation of benzoin to benzil with air as the “green” oxidizing reagent. The effects of temperature, base and solvent on M-Salen catalyzed oxidation of benzoin had been examined and optimized. The catalysis results showed that Co-Salen and Fe-Salen complexes were efficient to catalyze the oxidation reaction with yields over 80% while the catalytic activities of other three M-Salen complexes were poor. Moreover, the Co-Salen catalysis system could be reused three times with satisfied yield.

MAGNETIC SUBSTANCE

The present disclosure relates to a ferromagnetic substance containing a crystal of a metal complex molecule in which a heterocycle is bonded to metal, the metal of the metal complex molecule is bonded to the metal of another metal complex via oxygen as a electron donor, and the ferromagnetic substance has a ferromagnetic property balanced with stability of crystals based on a metal—electron donor—metal bond angle that is from 130° to 160°. The present disclosure also relates to a drug containing, as a principal component, the crystal of the metal complex molecule.

Room temperature hydrophosphination using a simple iron salen pre-catalyst

Phosphines are fundamentally important to the fine chemicals, pharmaceutical and agrochemical industries. Reported is the first example of alkene hydrophosphination using a designed iron pre-catalyst which yields the anti-Markovnikov products in high yield at room temperature. The phosphine products are excellent pro-ligands for Fe-catalyzed Negishi cross-coupling. This journal is

MAGNETIC COMPOSITION, AND METHOD FOR PRODUCING SAME

A magnetic composition containing a metal-salen complex compound which can be securely guided by a magnetic field to a target area to be preferably treated, and a method for producing the magnetic composition are provided. The magnetic composition is prepared by dispersing magnetic particles, which are obtained by coating a metal-salen complex compound with a dispersant, in a polar solvent by means of the dispersant. Furthermore, the magnetic composition production method includes a first step of mixing the metal-salen complex compound with the dispersant in an organic solvent and coating the metal-salen complex compound with the dispersant and a second step of dispersing the metal-salen complex in a polar solvent.

METAL-SALEN COMPLEX COMPOUND AND PRODUCTION METHOD FOR SAME

The present invention provides a metal-salen complex compound having a controlled grain size that enables the metal-salen complex compound to exert its pharmacological effects as a medicine, at a target region. This metal-salen complex compound is composed of the following that has a crystal grain size of 8 μm or less, and that is represented by the chemical formula below. N,N'-Bis(salicylidene)ethylenediamine metal M is Fe, Cr, Mn, Co, Ni, Mo, Ru, Rh, Pd, W, Re, Os, Ir, Pt, Nd, Sm, Eu, or Gd.

AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND

The present invention provides a drug using the magnetic properties of a metal salen complex as represented by the following general formula in order to magnetize the intended drug by chemically binding the drug to a metal salen complex so that the drug can be delivered to the target diseased site. The drug can be delivered to the diseased site using the magnetic properties of the drug per se without using a carrier made of a magnetic substance as in the conventional methods.

Formation in Solution, Synthesis, and Electrochemical Study of Oxalato Complexes of N,N'-Ethylenebis(salicylideneiminato)-chromium(III) and -iron(III): Crystal Structures of Piperidinium (oxalato-O1O2)-chromate(III) and ferrate(III)

Two new mononuclear complexes of formula and the binuclear *H2O, (3), where Hpip=piperidinium, salen=N,N'-ethylenebis(salycilideneiminate), and ox=oxalate, have been synthesized.Compounds (1) and (2) are isostructural, monoclinic, space group P21/n, Z=4, with a=24.425(3), b=6.847(1), c=14.271(2) Angstroem, and β=100.95(2) deg for (1) and a=24.363(4), b=6.991(2), c=14.105(3) Angstroem, and β=98.76(2) deg for (2).The stucture of (1) was solved by direct methods whereas that of (2) was solved by isomorphous replacement from the co-ordinates of (1).Both structures consist of (1-) mononuclear anions and piperidinium cations.The presence of the bidentate oxalate ligand in both complexes forces the salen ligand to adopt the non-planar cis-β configuration.The metal ions exhibit distorted octahedral geometry with the two co-ordinated oxygen atoms of the oxalate ligand and an oxygen and a nitrogen atom from the salen defining the best equatorial plane.The remaining two co-ordinating atoms of the quadridentate Schiff base are bent away from the oxalate ligand.The stability constant of the complex (1-) as well as the acidity constants of the complex (1+) have been determined by potentiometry in aqueous solution: log β1=4.80+/-0.03, pKa1=7.54+/-0.01, and pKa2=10.47+/-0.01 (25 deg C, 0.1 mol dm-3 NaNO3).Complexes (1) and (2) undergo one-electron reduction at a platinum electrode in dimethyl sulphoxide solution.The reduction process is totally irreversible due to an inner-sphere redox reaction in the case of Cr(III) and to the dissociation of the anionic oxalate ligand in the case of Fe(III).A reactivity scheme is proposed to explain their different electrochemical behaviour.