142155-43-9Relevant articles and documents
1-METHYLPYRAZOLE MODULATORS OF SUBSTANCE P, CALCITONIN GENE-RELATED PEPTIDE, ADRENERGIC RECEPTOR, AND/OR 5-HT RECEPTOR
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Page/Page column 34, (2010/11/05)
The present invention relates to new 1-methylpyrazole modulators of substance P release, calcitonin gene-related peptide activity, adrenergic receptor activity, and/or 5 -HT receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
Utilization of aryl(or heteroaryl)azolylcarbinol derivatives in the preparation of a medicament for the treatment of troubles mediated by an excess of substance P
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, (2008/06/13)
The present invention relates to the use of derivatives of aryl (or heteroaryl) azolylcarbinols of general formula (1) of the specification, as well as their physiologically acceptable salts, in the manufacture of medicaments, useful in human and/or veterinary therapy, for the treatment of disorders that are mediated by an excess of substance P, and especially disorders of the central nervous system such as anxiety, depression, schizophrenia, manic depressive psychosis, sexual dysfunction, drug addiction, cognitive disorders, and locomotive disorders.
Process for obtaining enantiomers of cis-olirtine
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, (2008/06/13)
PCT No. PCT/ES98/00223 Sec. 371 Date Feb. 1, 2000 Sec. 102(e) Date Feb. 1, 2000 PCT Filed Jul. 31, 1998 PCT Pub. No. WO99/07684 PCT Pub. Date Feb. 18, 1999The procedure comprises (a) the enantioselective reduction of a pro-chiral ketone (III) by using a r