14252-80-3 Usage
Uses
Sodium channel blocker, local anesthetic
Biological Functions
Bupivacaine hydrochloride (Marcaine, Sensorcaine)
has particularly long action, and some nerve blocks last
more than 24 hours; this is often an advantage for postoperative
analgesia. Its use for epidural anesthesia in
obstetrics has attracted interest because it can relieve
the pain of labor at concentrations as low as 0.125%
while permitting some motor activity of abdominal
muscles to aid in expelling the fetus. The lower concentration
minimizes the possibility of cardiac toxicity.
Fetal drug concentrations remain low, and drug-induced
neurobehavioral changes are not observed in the newborn.
Bupivacaine also is approved for spinal anesthesia
and is approximately four times more potent and more
toxic than mepivacaine and lidocaine. It can be used
with or without epinephrine.
Uses
antineoplastic
Chemical Properties
White Solid
Brand name
Marcaine (Hospira); Sensorcaine
(AstraZeneca).
InChI:InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H