Distribution of Bupivacaine hydrochloride (cas 14252-80-3) after sciatic and femoral nerve blocks in cats: A magnetic resonance imaging study

Add time:07/18/2019    Source:sciencedirect.com

The objective of this study was to evaluate the distribution of Bupivacaine hydrochloride (cas 14252-80-3) using magnetic resonance imaging (MRI) after electrical nerve stimulator (ENS)-guided sciatic (ScN) and femoral (FN) nerve blocks in cats. Six adult cats (body weight 4.8 ± 0.6 kg) were anesthetized with acepromazine-buprenorphine-propofol-isoflurane. Transverse and sagittal plan sequences of pelvic limbs were obtained using a high-field magnet (1.5 T). Afterwards, the ScN and FN blocks (one block per limb) were performed using 0.1 mL/kg of bupivacaine 0.5% per site and the MRI sequence was repeated after each block. The injection was considered successful when bupivacaine was in contact with the nerve. Injectate location and complications were recorded. The length (mm) of contact (spread) between bupivacaine and nerves was measured and classified as fair (< 15 mm) or adequate (≥ 15 mm). Five out of six ScN injections were successful; of these, four had adequate spread over the nerve [26 (13–39) mm]. All FN injections were successful, but in one case bupivacaine was administered over the motor branch of FN, distally to the bifurcation between the femoral and saphenous nerve. It was not possible to measure neither the length of contact between bupivacaine and FN nor to identify iatrogenic trauma caused by the injections.MRI can be used for the evaluation of bupivacaine distribution, but not complications, following ENS-guided ScN and FN blocks in cats. Despite most of the injections were considered successful, individual variability regarding the injectate location may explain differences in efficacy in the clinical setting.

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