143317-59-3

Basic information

• Product Name: (R)-METHYL 1-BENZYL-5-OXOPYRROLIDINE-2-CARBOXYLATE
• Synonyms: (R)-METHYL 1-BENZYL-5-OXOPYRROLIDINE-2-CARBOXYLATE
• CAS NO: 143317-59-3
• Molecular Formula: C₁₃H₁₅NO₃
• Molecular Weight: 233.26
• Mol File: 143317-59-3.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-METHYL 1-BENZYL-5-OXOPYRROLIDINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-METHYL 1-BENZYL-5-OXOPYRROLIDINE-2-CARBOXYLATE(143317-59-3)
• EPA Substance Registry System: (R)-METHYL 1-BENZYL-5-OXOPYRROLIDINE-2-CARBOXYLATE(143317-59-3)

Safety Data

• Hazardous Substances Data: 143317-59-3(Hazardous Substances Data)

Usage

General Description

(R)-METHYL 1-BENZYL-5-OXOPYRROLIDINE-2-CARBOXYLATE is a chemical compound that belongs to the class of pyrrolidine carboxylates. It is a chiral molecule with a specific three-dimensional arrangement of atoms. (R)-METHYL 1-BENZYL-5-OXOPYRROLIDINE-2-CARBOXYLATE has potential applications in pharmaceutical and chemical industries, particularly in the synthesis of various drugs and bioactive molecules. Its unique structure makes it a valuable building block for the development of new products with specific properties and functions. Additionally, it may also have potential uses in research and development of new therapeutic agents.

Upstream product

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• 67-56-1 methanol 
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Relevant articles and documents

THIAZOLE DERIVATIVES AS PROTEIN SECRETION INHIBITORS

Provided herein are secretion inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same, wherein the compound has a structure of Formula (I), (II), or (III).

Synthesis and evaluation of dual antiplatelet activity of bispidine derivatives of N-substituted pyroglutamic acids

N-aralkylpyroglutamides of substituted bispidine were prepared and evaluated for their ability to inhibit collagen induced platelet aggregation, both in vivo and in vitro. Some compounds showed high anti-platelet efficacy (in vitro) of which six inhibited

Synthesis and identification of chiral aminomethylpiperidine carboxamides as inhibitor of collagen induced platelet activation

A series of chiral lactam carboxamides of aminomethylpiperidine were synthesized and investigated for the collagen induced in vitro anti-platelet efficacy and collagen plus epinephrine induced in vivo pulmonary thromboembolism. The compound 31a (30 μM/kg) displayed a remarkable antithrombotic efficacy (60% protection) which was sustained for more than 24 h and points to its excellent bioavailability. The compounds 31a (IC50 = 6.6 μM) and 32a (IC50 = 37 μM), as well as their racemic mixture 28i (IC50 = 16 μM) significantly inhibited collagen-induced human platelet aggregation in vitro. Compound 34c displayed dual mechanism of action against both collagen (IC50 = 3.3 μM) and U46619 (IC50 = 2.7 μM) induced platelet aggregation. The pharmacokinetic study of 31a indicated very faster absorption, prolonged and constant systemic exposure and thereby exhibiting better therapeutic response.