3376-59-8

Usage

Uses

Used in Personal Care and Cosmetic Industry:
2,3-dihydroxypropyl benzoate is used as a stabilizer and fragrance ingredient for its ability to enhance the scent and shelf life of personal care and cosmetic products.
Used in Skincare Formulations:
2,3-dihydroxypropyl benzoate is used as an antioxidant preservative to protect skincare formulations from oxidation, ensuring their stability and efficacy.
Used in Moisturizing Products:
2,3-dihydroxypropyl benzoate is used as a humectant to help maintain skin hydration by attracting and retaining moisture in the skin.
Used in Antioxidant Formulations:
2,3-dihydroxypropyl benzoate is used as an antioxidant to neutralize free radicals and protect the skin from environmental stressors, thus promoting skin health and preventing premature aging.

InChI:InChI=1/C10H12O4/c11-6-9(12)7-14-10(13)8-4-2-1-3-5-8/h1-5,9,11-12H,6-7H2

Upstream product

• 816-41-1 sodium 2,3-dihydroxypropoxide 
• 98-88-4 benzoyl chloride 
• 71-43-2 benzene 
• 582-25-2 Potassium benzoate 
• 96-24-2 3-monochloro-1,2-propanediol 
• 56-81-5 glycerol 
• 65-85-0 benzoic acid 
• 58163-60-3 4-benzoyloxymethyl-2-ethyl-[1,3,2]dioxaborolane 
• 1708-39-0 1,2-benzylideneglycerol 
• 98760-27-1 4-benzoyloxymethyl-2,2-dimethyl-[1,3]dioxolane 
• 98760-25-9 oxiran-2-ylmethyl benzoate 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 97356-11-1 5-benzoyloxy-2-phenyl-[1,3]-dioxane 

Downstream Products

• 13495-39-1 1-benzoyloxy-2,3-bis-(4-nitro-benzoyloxy)-propane 
• 861366-48-5 glycerol-α benzoate-β-(4-nitro benzoate) 
• 22397-01-9 4-benzoyloximethyl-[1,3]dioxolane 
• 29751-66-4 1-Benzoyloxy-3-hydroxy-2-propanone 
• 112579-45-0 3-benzoyloxy-2-hydroxy-propionaldehyde 
• 64904-47-8 2-benzoyloxyacetaldehyde 
• 614-33-5 glyceryl tribenzoate 
• 91497-38-0 4-benzoyloxymethyl-2-methyl-[1,3]dioxolane 
• 56-81-5 glycerol 
• 101597-44-8 (2-phenyl-1,3-dioxolan-4-yl)methyl benzoate 
• 121564-15-6 [3-[tert-butyl(dimethyl)silyl]oxy-2-hydroxypropyl] benzoate 
• 143919-90-8 2-benzoyloxymethyl-5-acethoxy-1,3-oxathiolane 
• 358348-70-6 cis/trans-2-benzoyloxymethyl-5-(cytosin-1'-yl)-1,3-oxathiolane 
• 164152-29-8 (-)-1-benzoyl-2,3-di-p-toluenesulfonyl glycerol 

Relevant academic research and scientific papers

3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS

Compounds of formula (I) wherein Het1, Het2, R1, R2 and R3 are as defined in the description. Medicaments.

HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS

The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and

Assessing biocatalysis using dihydrolevoglucosenone (Cyrene) as versatile bio-based (co)solvent

An emerging biogenic aprotic solvent is the cellulose-derived dihydrolevoglucosenone, or 6,8-dioxabicyclooctanone (Cyrene). This paper explores the use of Cyrene in lipase-catalyzed biotransformations, both in aqueous solutions – as co-solvent – as well a

Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity

Mincle, expressed in activated phagocytes, recognizes the lipid ligand to activate the innate immune system. We have synthesized glycerol derivatives possessing simple alkyl chains or aromatic rings and elucidated their structure-activity relationships us

Preparation method for emtricitabine isomer

The invention discloses a preparation method for an embritabine isomer. The preparation method comprises the following steps: with Solketal as a starting material, allowing the Solketal to undergo a six-step reaction of esterification, hydrolysis, oxidation, condensation cyclization, acetylation and glycosylation condensation so as to synthesize four mixture intermediates of emtricitabine; and splitting the four isomer intermediates into a cis-isomer mixture and a trans-isomer mixture through a chiral reagent. According to the invention, by adoption of a simple starting material, a mixture forsplitting key intermediates of four optical isomers of the emtricitabine is synthesized through the six-step reaction, and chiral acid is utilized to split the four isomers into a mixture of cis andtrans isomers, so the preparation method provided by the invention has the advantages of simple and convenient operation, high yield and high isomer chiral purity.

Industrial preparation method of 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane

The invention discloses an industrial preparation method of 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane. The industrial preparation method of the 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane comprises the steps that (1) carboxylic acid monoglyceride is prepared by esterification reaction, specifically, glycerol and carboxylic acid are used as raw materials, and under the condition of acidic catalyst,the dehydration reaction is carried out under the condition of 90-150 DEG C for 0.5-4h to obtain the carboxylic acid monoglyceride; (2) ketal cyclization reaction is carried out, specifically, the carboxylic acid monoglyceride and acetone are controlled to perform the cyclization reaction at 20-50 DEG C for 0.5-3 h under the condition of acid catalyst reaction to obtain a cyclization intermediateproduct; and (3) hydrolysis reaction is carried out, specifically, the intermediate product obtained in the step (2) is added into an alkaline solution, the mixture reacts for 0.5-1 h at 20-50 DEG C,and the 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane is obtained. The industrial preparation method of the 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane has the characteristics of green and environment-friendly process, high selectivity of industrial reaction and high conversion rate of raw materials.

Utilization of hexabromoacetone for protection of alcohols and aldehydes and deprotection of acetals, ketals, and oximes under UV irradiation

Hexabromoacetone (HBA) was efficiently used for the protection of alcohols and aldehydes and deprotection of benzaldehyde dimethyl acetal, solketal, and other acetals and ketals. In only 10?min, the protection of glycerol yielded 90% of solketal and protection of benzaldehyde gave 95% of benzaldehyde dimethyl acetal. The deprotection of benzaldehyde dimethyl acetal under UV irradiation gave over 90% yield of benzaldehyde within 15?s using only 2.5?mol% of HBA. HBA was also successfully used for deoximation. Solvent was found to play an important role in the efficiency of HBA for these reactions.

ANTIBACTERIAL COMPOSITION INCLUDING BENZOIC ACID ESTER AND METHODS OF INHIBITING BACTERIAL GROWTH UTILIZING THE SAME

Antibacterial compositions and methods for inhibiting bacterial growth are disclosed. The antibacterial compositions can include a carrier and an antibacterial agent including a benzoic acid ester. The benzoic acid ester can have a carbon chain having a length of two to ten. The benzoic acid ester can have a hydroxyl group on the carbon chain.

Green Organocatalytic Dihydroxylation of Alkenes

An inexpensive, green, metal-free one-pot procedure for the dihydroxylation of alkenes is described. H2O2 and 2,2,2-trifluoroacetophenone were employed as the oxidant and organocatalyst, respectively, in this highly sustainable protocol in which a variety of homoallylic alcohols, aminoalkenes, and simple alkenes were converted into the corresponding polyalcohols in good to excellent yields. This process takes advantage of an epoxidation reaction followed by an acidic treatment in which water participates in the ring opening of the in situ prepared epoxide to lead to the desired product.

New chemoenzymatic synthesis of (±)-n-(2-hydroxyethyl)-n,n-dime thyl- 2,3-bis(tetradecyloxy)-1-propanammonium bromide (dmrie)

Background: Cytofectins are a class of positively charged lipid molecules that can facilitate the functional entry of polynucleotides, macromolecules, and small molecules into living cells, escaping lysosomal degradation. One of the most potent cytofectins, dimyristoyl Rosenthal inhibitor ether (DMRIE), is presently being used to deliver differents active molecules into animal and human diseased tissues. To our knowledge, two synthetic routes for the preparation of DMRIE have so far been reported. One of them is based on the reaction of epichlorhydrin with either dimethylamine chloride or dimethylamine using an alkaline solution as solvent. The main disadvantage of these routes is the formation of 3-(N,N-diamino)-1,2-propanediol. In summary, the synthetic routes mentioned use epichlorohydrin or glycidol as starting materials, both of which have been described as carcinogenic agents. Additionally, sometimes the reaction conditions are drastic. An alternative route for the preparation of other cytofectins is the use of glycerol as the starting material. Glycerol is a non-carcinogenic compound, but its use as starting material results in an increased number of steps of this reaction, generating an increase in the total time of synthesis and the formation of a greater amount of waste and scrap. Based on the above, here we propose a new chemoenzymatic synthetic strategy using glycerol as a starting material. Methods: Initially, glycerol and vinyl benzoate were mixed in presence of Mucor miehei lipase (Lipozyme), it is converted into corresponding mono-benzoate (±)-1. Finally, DMRIE was obtained by the reaction of bromide (±)-3 with 2- dimethylaminoethanol (DMAE). Results: We studied the stability of compound (±)-1 under the working conditions applied in the preparation of intermediate alcohol (±)-2. Additionally, we study different experimental parameters. Conclusion: In summary, a new chemoenzymatic synthetic route was developed for the DMRIE using glycerol as the starting material. We studied and optimized various experimental parameters of the various synthetic steps, and reached to develop the methodology to multigram scale, which compared to processes reported so far, has the advantages of fewer synthetic steps, the use of less aggressive reagents environment and generating fewer waste allowed to obtain the desired product; which results in a viable method for synthesizing analogs to DMRIE.