Welcome to LookChem.com Sign In|Join Free

CAS

  • or

144010-85-5

Post Buying Request

144010-85-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

144010-85-5 Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 144010-85-5 differently. You can refer to the following data:
1. The (R)-enantiomer metabolite of Citalopram, an inhibitor of serotonin (5-HT) uptake. Used as an antidepressant.
2. The (R)-enantiomer metabolite of Citalopram, an inhibitor of serotonin (5-HT) uptake. (R)-Desmethyl Citalopram hydrochloride is used as an antidepressant

Check Digit Verification of cas no

The CAS Registry Mumber 144010-85-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,0,1 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 144010-85:
(8*1)+(7*4)+(6*4)+(5*0)+(4*1)+(3*0)+(2*8)+(1*5)=85
85 % 10 = 5
So 144010-85-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H19FN2O.ClH/c1-22-10-2-9-19(16-4-6-17(20)7-5-16)18-8-3-14(12-21)11-15(18)13-23-19;/h3-8,11,22H,2,9-10,13H2,1H3;1H/t19-;/m1./s1

144010-85-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-Desmethyl Citalopram Hydrochloride

1.2 Other means of identification

Product number -
Other names (1R)-1-(4-fluorophenyl)-1-[3-(methylamino)propyl]-3H-2-benzofuran-5-carbonitrile,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:144010-85-5 SDS

144010-85-5Relevant articles and documents

Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs

Mehr-Un-Nisa,Munawar, Munawar A.,Lee, Yeon Sun,Rankin, David,Munir, Jawaria,Lai, Josephine,Khan, Misbahul A.,Hruby, Victor J.

, p. 1251 - 1259 (2015)

A series of opioid and serotonin re-uptake inhibitors (SSRIs) bifunctional ligands have been designed, synthesized, and tested for their activities and efficacies at μ-, δ- and κ opioid receptors and SSRIs receptors. Most of the compounds showed high affinities for μ- and δ-opioid receptors and lower affinities for SSRIs and κ opioid receptors. A docking study on the μ-opioid receptor binding pocket has been carried out for ligands 3-11. The ligands 7 and 11 have displayed the highest binding profiles for the μ-opioid receptor binding site with ΔGbind (-12.14 kcal/mol) and Ki value (1.0 nM), and ΔGbind (-12.41 kcal/mol) and Ki value (0.4 nM), respectively. Ligand 3 was shown to have the potential of dual acting serotonin/norepinephrine re-uptake inhibitor (SNRI) antidepressant activity in addition to opioid activities, and thus could be used for the design of multifunctional ligands in the area of a novel approach for the treatment of pain and depression.

Preparation method of escitalopram oxalate demethylation impurity

-

Paragraph 0017, (2017/08/29)

The invention provides a brand-new preparation method of 1-(4- fluorophenyl)-1-(3-(fluorophenyl)propyl)-1,3-dihydroisobenzofiaran-5-formonitrile as an escitalopram oxalate process impurity. The brand-new preparation method provides a reference for qualitatively and quantitatively analyzing impurity conditions in a finished product of escitalopram oxalate, has an important effect on quality control of the escitalopram oxalate, and can promote safe medication of depressed patients.

Novel and high affinity fluorescent ligands for the serotonin transporter based on (S)-citalopram

Kumar, Vivek,Rahbek-Clemmensen, Troels,Billesb?lle, Christian B.,Jorgensen, Trine Nygaard,Gether, Ulrik,Newman, Amy Hauck

, p. 696 - 699 (2014/07/07)

Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hSERT, hDAT, and hNET, respectively) and for binding at SERT, in transiently

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 144010-85-5