1441-98-1Relevant academic research and scientific papers
Oxidation of organoselenium compounds. A study of chemoselectivity of phenylacetone monooxygenase
Andrade, Leandro H.,Pedrozo, Eliane C.,Leite, Henrique G.,Brondani, Patricia B.
, p. 63 - 66 (2012/02/13)
Organoselenium acetophenones oxidation using enzymatic reactions has been developed and chemoselectivity of phenylacetone monooxygenase (PAMO) with selenium-containing ketones has been explored. We discovered that this biocatalyst prefers selenium oxidation, which leads to selenoxide in excellent conversion, over Baeyer-Villiger oxidation.
Preparation of chiral organochalcogeno-α-methylbenzyl alcohols via biocatalysis. The role of Daucus carota root
Comasseto, Jo?o V.,Omori, álvaro T.,Porto, André L. M.,Andrade, Leandro H.
, p. 473 - 476 (2007/10/03)
A series of organochalcogeno acetophenones 3 has been submitted to the action of enzymes from Daucus carota root. Some of the chalcogeno ketones tested afforded the chiral organochalcogeno-α-methylbenzyl alcohols 4 in excellent enantiomeric excesses (>99%), under mild and environmentally friendly conditions. The stereoselectivity of the reduction is in accordance with Prelog's rule. Enzymatic kinetic resolution as alternative process was used to obtain the chiral ortho-organochalcogeno-α-methylbenzyl alcohols in excellent enantiomeric excess (>99%).
