107020-80-4

Basic information

• Product Name: N-Acetyl-DL-cyclohexylglycine
• Synonyms: N-Acetyl-DL-cyclohexylglycine;2-AcetaMido-2-cyclohexylacetic acid
• CAS NO: 107020-80-4
• Molecular Formula: C₁₀H₁₇NO₃
• Molecular Weight: 199.25
• Mol File: 107020-80-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 428.641 °C at 760 mmHg
• Flash Point: 213.035 °C
• Appearance: /
• Density: 1.134 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N-Acetyl-DL-cyclohexylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-DL-cyclohexylglycine(107020-80-4)
• EPA Substance Registry System: N-Acetyl-DL-cyclohexylglycine(107020-80-4)

Safety Data

• Hazardous Substances Data: 107020-80-4(Hazardous Substances Data)

Usage

General Description

N-Acetyl-DL-cyclohexylglycine, also known as N-acetylcyclohexylglycine, is a chemical compound that contains an acetyl group and a cyclohexylglycine moiety. It is a derivative of the amino acid glycine and is commonly used as a chiral building block in organic synthesis. It is known for its ability to function as a chiral ligand in homogeneous catalysis, particularly in asymmetric hydrogenation reactions. N-Acetyl-DL-cyclohexylglycine has also been studied for its potential pharmaceutical applications, particularly in the development of new drugs for various medical conditions. Additionally, it has demonstrated potential antioxidant properties, making it an interesting candidate for further research in the field of health and wellness.

InChI:InChI=1/C10H17NO3/c1-7(12)11-9(10(13)14)8-5-3-2-4-6-8/h8-9H,2-6H2,1H3,(H,11,12)(H,13,14)

Upstream product

• 60-35-5 acetamide 
• 201230-82-2 carbon monoxide 
• 2043-61-0 cyclohexanecarbaldehyde 
• 75-05-8 acetonitrile 
• 110-83-8 cyclohexene 
• 5664-29-9 2-cyclohexylglycine 
• 108-24-7 acetic anhydride 

Downstream Products

• 14001-39-9 N-(cyclohexylidenemethyl)acetamide 
• 14328-51-9 (2S)-amino(cyclohexyl)ethanoic acid 
• 14328-67-7 N-Tosyl-S-benzyl-cysteinyl-tyrosyl-(2-cyclohexyl-2-amino-essigsaeuremethylester) 
• 145618-11-7 (S)-amino(cyclohexyl)acetic acid methyl ester 

Relevant articles and documents

First amidocarbonylation with nitriles for the synthesis of N-acyl amino acids

A new and efficient one-pot synthesis of N-acyl-α-amino acids by amidocarbonylation is described. Starting from aldehydes, nitriles and carbon monoxide in the presence of acid and palladium catalysts the desired N-acyl amino acids are obtained in good yie

A study of amidocarbonylation reactions catalyzed by Pd/HZSM-5

A HZSM-5-supported palladium catalyst, which was prepared by the conventional impregnation method, was utilized in amidocarbonylation reactions. Several important parameters were optimized to give moderate to excellent yields. The catalyst recycling of Pd/HZSM-5, for the first time, was achieved for at least four run times without depreciation of catalytic activity. The studies of TEM images revealed that agglomeration of the palladium species of Pd/ HZSM-5 catalyst was avoided after reaction, which was quite different from the case of Pd/C catalyst.

Amidoearbonylation of aldehydes utilizing cobalt oxide-supported gold nanoparticles as a heterogeneous catalyst

Cobalt oxide-supported gold-nanoparticles-catalyzed transformation of aldehydes and their equivalents to N-acyl-α-arnino acids was achieved. The desired products were obtained in moderate to excellent yields under milder reaction conditions than previous reports employing octacarbonyldicobalt as a catalyst. Copyright

Efficient synthesis of N-acyl-α-amino acids via polymer incarcerated palladium-catalyzed amidocarbonylation

A novel polymer incarcerated Pd catalyst (PI Pd 7c) was synthesized from amide-containing polymer 6b, and this catalyst was shown to be effective in amidocarbonylation, which is a versatile one-pot method for the preparation of N-acyl-α-amino acids. The reactions proceeded smoothly with a wide variety of substrates, and no leaching of the Pd metal to the reaction mixture was detected.