14586-35-7

Usage

Uses

Used in Biodiesel Production:
COL ACETATE is used as a solvent for the enzymatic production of biodiesel. The eutectic ionic liquid mixture formed by combining COL ACETATE with glycerol, a hydrogen-bond donor, is less viscous, biodegradable, and shows high lipase compatibility, making it a desirable solvent for this application.
Used in Cellulose Dissolution:
COL ACETATE is used as a solvent for dissolving microcrystalline cellulose. As a bioionic liquid, it offers an efficient method for dissolving cellulose, which can be beneficial in various industrial applications, such as the production of biofuels, chemicals, and materials derived from biomass.
Used in Pharmaceutical Applications:
Although not explicitly mentioned in the provided materials, COL ACETATE, being a choline-derivative, may have potential applications in the pharmaceutical industry. Choline and its derivatives are known to play a role in various biological processes, and their use in drug development and formulation could be a possible application for COL ACETATE.

InChI:InChI=1/C5H14NO.C2H4O2/c1-6(2,3)4-5-7;1-2(3)4/h7H,4-5H2,1-3H3;1H3,(H,3,4)/q+1;/p-1

Upstream product

• 64-19-7 acetic acid 
• 78-73-9 cholinium hydrogen carbonate 
• 67-48-1 choline chloride 
• 631-61-8 ammonium acetate 
• 83846-92-8 choline choline dihydrogen phosphate 
• 127-09-3 sodium acetate 
• 127-08-2 potassium acetate 
• 123-41-1 cholin hydroxide 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 79-20-9 acetic acid methyl ester 

Downstream Products

• 1321816-57-2 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4- d]pyrimidine-5-carboxylic acid (2-hydroxyethyl)trimethylammonium 

Relevant academic research and scientific papers

A green and sustainable approach to utilize bio-ionic liquids for the selective precipitation of high purity agarose from an agarophyte extract

A few choline based bio-ionic liquids (bio-ILs) were employed for the first time for the selective precipitation of agarose from the hot seaweed extract of Gracilaria dura (an agarophyte) under ambient conditions. The method thus developed is much greener and economical in comparison with the methods widely practiced for agarose production. Among the bio-ILs, choline laurate was found to be the most effective for the isolation of agarose with a lower usage level (4.0%, w/w) with the yield of 14.0 ± 0.5% w/w. Agarose obtained by this process had the desired properties required for molecular biological applications and gel electrophoresis. Furthermore the bio-ILs were recycled and reused for subsequent batches of agarose isolation without compromising the yield and quality of biopolymers.

Correlation between Ionic Liquid Cytotoxicity and Liposome–Ionic Liquid Interactions

This study aims at extending the understanding of the toxicity mechanism of ionic liquids (ILs) using various analytical methods and cytotoxicity assays. The cytotoxicity of eight ILs and one zwitterionic compound was determined using mammalian and bacter

Degradation of poly(ethylene terephthalate) catalyzed by metal-free choline-based ionic liquids

Glycolysis of poly(ethylene terephthalate) (PET) is a prospective way for degradation of PET to its monomer bis(hydroxyethyl) terephthalate (BHET) which can be polymerized again to form new qualified PET materials, and hence provides possibilities for a permanent loop recycling. However, most of the reported glycolysis catalysts are metal-based, leading to high cost and negative environmental impact. In this study, we developed a series of choline-based ionic liquids (ILs) without metals and applied them in the glycolysis of PET as catalysts. Choline acetate ([Ch][OAc]), which is cheaper, more biologically compatible and environmentally friendly in comparison with conventional imidazolium metal-based ILs, can achieve a comparable or even better performance than them. Under optimum conditions (PET (5.0 g), ethylene glycol (EG) (20.0 g), [Ch][OAc] (5 wt%), 180 °C, 4 h, atmospheric pressure), the yield of BHET reached up to 85.2%. Additionally, the reaction kinetics was studied and proved to be the shrinking-core model. The apparent activation energy is 131.31 kJ mol-1, and the pre-exponential factor is 1.21 × 1013 min-1. Finally, based on the experimental results and density functional theory (DFT) calculations, a possible mechanism was proposed. The promotion of the glycolysis reaction is attributed to the activation of EG by the formation of hydrogen bonds between EG and the IL.

Ionic liquid-based synthesis-a low-temperature route to nanophosphates

Endless Phossibilities: Microwave synthesis, with phosphate ionic liquids acting as reaction partner, solvent, and in-situ stabilizer all-in-one, allows for a fast, facile, and mild access to nanometer-sized orange-red emitting phosphors. The phosphors show excellent photophysical performance.

Understanding the destructuration of starch in water-ionic liquid mixtures

The destructuration of native maize starch in mixtures of water and ionic liquids (ILs) containing acetate anions was studied in dynamic heating conditions, combining calorimetry, rheology, microscopy and chromatographic techniques. A phase diagram of starch in water-IL solutions was established. The phase transitions undergone by starch include the typical endothermic gelatinization phenomenon for IL-water ratios lower than 0.5, while for mixtures with a higher ionic liquid content, a complex exothermic phenomenon combining mild degradation and solubilization takes place. This results in an optimum destructuration temperature as low as 40-50 °C for an IL-water ratio close to 0.7. In addition, specific macromolecular chain breaking reactions appear to take place, depending on the nature of the cations present, resulting in different macromolecular structures of the recovered starch. These results suggest the possibility of using solvent media design for a controlled modification of starch macromolecular characteristics.

From waste to value-direct utilization of limonene from orange peel in a biocatalytic cascade reaction towards chiral carvolactone

In this proof of concept study we demonstrate direct utilization of limonene containing waste product orange peel as starting material for a biocatalytic cascade reaction. The product of this cascade is chiral carvolactone, a promising building block for thermoplastic polymers. Four different concepts were applied to augment limonene availability based on either water extraction solely, addition of extraction enhancers or biomass dissolution.

Novel biocompatible cholinium-based ionic liquids - Toxicity and biodegradability

The synthesis, characterisation and toxicological assessment of a new group of environmentally friendly ionic liquids are presented. Focussing on the toxic effect of the anion, the ionic liquids were designed by combining the benign cholinium cation, [NMe3(CH2CH2OH)]+, with a range of linear alkanoate anions ([CnH2n+1CO 2]-, n = 1-9), as well as two structural isomers (n = 3 or 4). The toxicity of these ionic liquids was evaluated using filamentous fungi as model eukaryotic organisms. Surprisingly, most of the tested species showed active growth in media containing extremely high ionic liquid concentrations, up to molar ranges in some cases. The biodegradability of these ionic liquids was assessed, and new biotechnological applications for them are proposed, e.g. as solvents for biopolymers. This study leads to the better understanding of the anion influence on the ionic liquid toxicity, but its core is the recognition that conscious design of ionic liquids can be used to deliver truly biocompatible salts without adversely affecting one of the most striking of their properties - their outstanding solvent ability.

Diazobicyclo[5.4.0]undec-7ene-ium and tetramethyl guanidium based ionic liquids enhanced thermal stability of xylose reductase at extreme pH through specific ion effect

As part of sustainable industrial bioprocesses, conversion of xylose from lignocellulosic biomass residues has gained attention and importance over recent decades. Xylitol is one such imperative metabolites which can be obtained in a single step conversion from xylose through enzymatic process employing xylose reductase. Xylose reductase from Debaryomyces nepalensis NCYC 3413 (DnXR) has proved to be potential candidate for this purpose due to its industrially superior characteristics compared to the enzymes from other sources. Ionic liquids have applications in various fields, especially in biotechnology, as a replacement of organic solvents as well as for efficient processes and improvement of existing process by enhancing the stability of biomolecules. In this study, effect of diazobicyclo[5.4.0]undec-7ene-ium (DBU), tetramethyl guanidium (TMG) based and Cholinium based ionic liquids on the activity and stability of DnXR was investigated in terms of thermodynamic parameters, half-life time as well as the intrinsic tryptophan fluorescence at pH 5.0, 7.0 and 10.0. [TMG][But] and [DBU][Acetate] were effective in improving the enzyme activity at pH 10.0 by 72% and 58%. [TMG][Acetate] increased the functional stability at pH 10.0 by 10-fold while maintaining the activity same as control and [DBU][Chloride] enhanced the half-life time by 8.5-fold at pH 5.0.

Synthesis and properties of room-temperature choline carboxylate zwitterionic ionic liquids as potential electrolytes

Choline carboxylate zwitterions were prepared by two different synthetic routes through esterification of choline salts with a range of anhydrides. Their conjugation with lithium bis(trifluoromethylsulfonyl) imide resulted in the formation of stable room-temperature ionic liquids. In view of their use as potential electrolytes the physicochemical characterization of these attractive ionic liquids was performed. These compounds presented a glass transition temperature between -43 and -34 °C, good thermal stability up to 2248C, densities above 1.44 gcm-3 at 25°C, and viscosities between 3.56 and 12.27 Pa s at 258C. In terms of conductivity the most promising ionic liquid showed an excellent conductivity between 8.66 105 Scm-1 at 258C and 1.8010-3 Scm-1 at 908C. These zwitterionic ionic liquids maintained a liquid state, and no dissociation was observed even after six months of storage at room temperature.

Investigation of salt effect of some inorganic salts and ionic liquids for ibuprofen in aqueous solutions of 1-propanol: volumetric, acoustic and viscometric studies

In this study, salt effect of sodium chloride, potassium chloride, choline acetate (ChAce), choline lactate (ChLac) and choline propionate (ChPro) for ibuprofen in aqueous solutions of 1-propanol were investigated using volumetric, acoustic and viscometric methods. Density, speed of sound and viscosity of quaternary systems (ibuprofen + water + 1-propanol + NaCl/KCl/ChAce/ChLac/ChPro) were measured at temperatures T = 288.15, 298.15 and 308.15 K. Limiting apparent molar volume and limiting apparent molar isentropic compressibility at infinite dilution were calculated using experimental density and speed of sound. Limiting apparent molar volume of ibuprofen increased in the presence of NaCl and KCl; whereas limiting apparent molar volume decreased in the presence of ionic liquids. Therefor NaCl and KCl have salting-out effect; whereas ChAce, ChLac and ChPro have salting-in effect. Also, molar free energy activation of solvent and solute were evaluated using viscosity data. The molar free energy activation of solute was greater than solvent; therefore ibuprofen has a maker structure nature in solvents (water + 1-propanol + NaCl/KCl/ChAce/ChLac/ChPro).