41349-15-9

Basic information

• Product Name: platinum(2+) azanide - ethanedioic acid (1:2:1)
• CAS NO: 41349-15-9
• Molecular Formula: C₂H₆N₂O₄Pt
• Molecular Weight: 317.164
• Mol File: 41349-15-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 365.1°C at 760 mmHg
• Flash Point: 188.8°C
• Vapor Pressure: 2.51E-06mmHg at 25°C
• CAS DataBase Reference: platinum(2+) azanide - ethanedioic acid (1:2:1)(CAS DataBase Reference)
• NIST Chemistry Reference: platinum(2+) azanide - ethanedioic acid (1:2:1)(41349-15-9)
• EPA Substance Registry System: platinum(2+) azanide - ethanedioic acid (1:2:1)(41349-15-9)

Safety Data

• Hazardous Substances Data: 41349-15-9(Hazardous Substances Data)

Usage

General Description

Platinum(2+) azanide-ethanedioic acid (1:2:1) is a chemical compound composed of platinum(II) cations, azanide anions, and ethanedioic acid molecules. The platinum(II) cations, also known as Pt2+, have a positive charge and are coordinated with the azanide anions, which contain nitrogen and display a negative charge. Ethanedioic acid, also known as oxalic acid, is a dicarboxylic acid containing two carboxyl groups. The ratio in the compound indicates that there are two ethanedioic acid molecules for every one platinum(II) azanide unit. This chemical compound may have various industrial and scientific applications, such as in catalysis, coordination chemistry, and material science.

Upstream product

• 41575-87-5 cis-diaminedinitroplatinum(II) 
• 144-62-7 oxalic acid 
• 16893-25-7 {Pt(2)Br2} 
• 583-52-8 potassium oxalate 
• 15663-27-1 cisplatin 
• 100-97-0 hexamethylenetetramine 
• 63700-88-9 cisplatin 
• 7664-41-7 ammonia 
• 6153-56-6 oxalic acid dihydrate 
• 7732-18-5 water 
• 62-76-0 sodium oxalate 
• 33081-83-3 bis(tetrabutylammonium)oxalate 

Downstream Products

• 16893-05-3 cis-diaammineplatinum(IV) tetrachloride 
• 15663-27-1 cisplatin 
• 7664-41-7 ammonia 
• 7440-06-4 platinum 
• 13601-52-0 cis-diamminedibromoplatinum(II) 

Relevant articles and documents

MONOMALEIMIDE-FUNCTIONALIZED PLATINUM COMPOUNDS FOR CANCER THERAPY

The present invention relates to novel monomaleimide-functionalized platinum compounds of formula (I), including in particular novel monomaleimide-functionalized oxaliplatin and carboplatin derivatives, as well as their use as medicaments, particularly for the treatment or prevention of cancer.

Synthesis and characterization of Pt(II) complexes with amine and carboxylato ligands. Crystal structure of (1,1-cyclobutanedicarboxylato)di(ethylamine)platinum(II)·H2O

Two methods for the synthesis of compounds of the type cis-PtA2X2 (A2 = bidentate amine or two monodentate amines and X2 = bidentate or two monodentate carboxylato ligands) were evaluated. The compounds were characterized by multinuclear NMR and IR spectroscopies. The 195PT NMR chemical shifts were in the range - 1615 to - 1976 ppm, the higher field values corresponding to the complexes containing bidentate ligands. The coupling constants 3J(195Pt-1H) are approximately 35 Hz, while the 2J(195Pt-1HN) are about 70 Hz. One coupling constant 2J(195Pt-13C) (53 Hz) was also measured. The crystal structure of the compound, cis-Pt(1,1-cyclobutanedicarboxylato)(C2H5NH2)2·H2O belongs to the P21/n space group with a=9.468(5), b =9.365(4), c = 16.473(7) A?, β = 105.08(3)°, Z = 4 and R1 = 0.0576. The Pt-N bond distances are 1.992(5) and 2.020(5) A?, while the Pt-O bonds are 2.000(4) and 2.015(4) A?. The molecules are held together by intermolecular H-bonds involving the lattice water molecules and the two free carbonyl O atoms and between the amino H atoms and the Pt-bonded C-O groups. (C) 2000 Elsevier Science S.A.