1462-84-6

Usage

Uses

Used in Chemical Synthesis:
2,3,6-TRIMETHYLPYRIDINE is used as a building block for the synthesis of various organic compounds due to its unique chemical structure and reactivity.
Used in Flavor and Fragrance Industry:
2,3,6-TRIMETHYLPYRIDINE is used as a flavoring agent for its characteristic aroma, adding a pleasant scent to various products.
Used in Pharmaceutical Industry:
2,3,6-TRIMETHYLPYRIDINE is used as an intermediate in the production of certain pharmaceutical compounds, contributing to the development of new drugs.
Used in Material Science:
2,3,6-TRIMETHYLPYRIDINE can be used as a component in the development of new materials, such as polymers and coatings, due to its chemical properties.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

2,3,6-TRIMETHYLPYRIDINE neutralizes acids in weakly exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.

Fire Hazard

Flash point data for 2,3,6-TRIMETHYLPYRIDINE are not available, however, 2,3,6-TRIMETHYLPYRIDINE is probably combustible.

InChI:InChI=1/C8H11N/c1-6-4-5-7(2)9-8(6)3/h4-5H,1-3H3

Upstream product

• 741668-77-9 3-(chloromethyl)-2,6-dimethylpyridine 
• 78-86-4 s-butyl chloride 
• 75-36-5 acetyl chloride 
• 75-05-8 acetonitrile 
• 74-99-7 prop-1-yne 
• 50-00-0 formaldehyd 
• 7664-41-7 ammonia 
• 67-64-1 acetone 
• 78-93-3 butanone 
• 582303-10-4 (2,6-dimethylpyridin-3-yl)methanol 
• 1721-13-7 ethyl 2,6-dimethylnicotinate 
• 38688-78-7 2,3,6-trimethyl-pyridine-1-oxide 
• 879133-16-1 4-chloro-2,3,6-trimethylpyridine N-oxide 
• 38594-55-7 2,3,6-Trimethyl-4-nitropyridine N-oxide 

Relevant academic research and scientific papers

Inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction

The invention concerns inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction, characterized by formula I wherein, X, Y and Z independently represent C or N; ------ is an optional double bond; n is 0 or 1; R1, R2, and R4 independently represent hydrogen, a chemical bond, C1-10 alkyl; C2-10 alkenyl; C2-10 alkinyl; aryl; aryl-C1-10 alkyl; C3-10 heterocyclyl; C5-10 heteroaryl; halo, CF3; NO2; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, arylalkyl, heterocyclyl, or heteroaryl being optionally substituted; R3, R5, and R6 independently represent hydrogen, C1-10alkyl; C2-10 alkenyl; C2-10 alkinyl; aryl; aryl-C1-10alkyl; C3-10 heterocyclyl; C5-10 heteroaryl; halo, CF3; NO2; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, heterocyclyl, or heteroaryl being optionally substituted; or R5 and R6 together form a 5- or 6-member aryl, heterocyclyl or heteroaryl group; R is hydrogen or C1-6 alkyl; R* is hydrogen, or C1-6 alkyl, or OH, wherein the optional substituents are preferably selected from the group of one to three OH, C1-6 alkyl, halo, NO2, C1-6 alkoxy, and CF3, or a pharmaceutically acceptable salt thereof.

Process for the preparation of a collidine and 2,3,5,6-tetramethyl pyridine

The present invention provides a process for synthesis of tri- and tetra-alkylated pyridines (i.e. collidines) in high yields by reacting methyl ethyl ketone with formaldehyde in presence of ammonia in gas phase in the presence of a zeolite catalyst which comprises of silica-alumina with atleast one metal ion and/or metal selected from the group consisting of lanthanum, lead, manganese, iron, copper and cobalt. This process provides eco-friendly, more economical and shape-selective heterogeneous method.

Ligand substitution kinetics and equilibria in the systems formed by tetrabromoaurate(III) anion and heterocyclic nitrogen donors

The kinetics of the forward and reverse reactions [AuBr4]- + am = [AuBr3(am)] + Br- has been studied in 95/5 vol % methanol/water mixtures at 25.0°C for am = pyridine and a variety of substituted pyridines. When there is methyl substitution on both the 2- and 6-positions, the low stability of the amine complexes precludes a study of the kinetics of their formation. However, they can be prepared and the kinetics of their decomposition are reported. The second-order rate constants for the forward and reverse reactions depend upon the amine basicity and take the form log kf2 = a(pKa) + b and log kr2 = -a(pKa) + b′ where a and a′ are independent of the extent of ortho substitution in the ligand. In contrast to the case for the chloro analogues, the reactions in both directions are retarded by 2(6)-methyl substituents in the pyridine ring, manifested by a change in b and b′.

Improved Catalytic Activity of Cyclopentadienylcobalt in the Preparation of Pyridines from Acetylenes and Nitriles

The catalytic activity of cyclopentadienylcobalt increases greatly upon introducing a methoxycarbonyl group into the cyclopentadienyl ring, and by carrying out the reaction with a rigorous exclusion of oxygen.Among the precursors we have examined, the most active one was z)(cot)> (Cpz = methoxycarbonyl-substituted cyclopentadienyl; cot = cyclooctatetraene) which can generate the active species at 100 deg C.

Tri- et tetraacylation des derives du propene : application a la synthese d'acyl-3 et de diacyl-3,5 pyridines

The acylation (acetylation, propionylation, isobutyrylation) of isopropyl chloride has been performed under Friedel-Crafts conditions (AlCl3).For the first time, products resulting from triacylation and tetraacylation have been obtained.Treatment with liquid ammonia affords the title compounds.Thus, sophisticated products are obtained readily from very cheap starting materials.