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3,4,6-tri-O-benzyl-1,2-O-(exo-methoxyethylidene)-β-D-mannopyranose is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

146864-77-9

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146864-77-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 146864-77-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,8,6 and 4 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 146864-77:
(8*1)+(7*4)+(6*6)+(5*8)+(4*6)+(3*4)+(2*7)+(1*7)=169
169 % 10 = 9
So 146864-77-9 is a valid CAS Registry Number.

146864-77-9Relevant articles and documents

Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and in Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates

Matovi?, Jelena,J?rvinen, Juulia,Sokka, Iris K.,Imlimthan, Surachet,Raitanen, Jan-Erik,Montaser, Ahmed,Maaheimo, Hannu,Huttunen, Kristiina M.,Per?niemi, Sirpa,Airaksinen, Anu J.,Sarparanta, Mirkka,Johansson, Mikael P.,Rautio, Jarkko,Ekholm, Filip S.

, p. 285 - 304 (2020/12/21)

Boron neutron capture therapy (BNCT) is a noninvasive binary therapeutic modality applicable to the treatment of cancers. While BNCT offers a tumor-targeting selectivity that is difficult to match by other means, the last obstacles preventing the full har

A five-component one-pot synthesis of phosphatidylinositol pentamannoside (PIM5)

Wang, Dong,Xiong, De-Cai,Ye, Xin-Shan

, p. 1340 - 1342 (2018/01/08)

A practical and efficient synthesis of phosphatidylinositol pentamannoside (PIM5) was achieved based on a five-component one-pot sequential glycosylation protocol with exclusive regio- and stereo-selectivity. Two regioselective sequential glycosylations on inositol and p-tolyl thioglycosides as the sole type of building blocks made this protocol to avoid the tedious protective group manipulations. This synthetic strategy provides access to other important glycolipids with similar structures.

ANTIBODY CONJUGATES AND METHODS OF MAKING THE ANTIBODY CONJUGATES

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Paragraph 0193, (2017/01/02)

Described herein are antibody conjugates and methods of making antibody conjugates.

Exploring glycosylation reactions under continuous-flow conditions

Cancogni, Damiano,Lay, Luigi

, p. 2873 - 2878 (2015/01/16)

The industrial development of carbohydrate-based drugs is greatly thwarted by the typical challenges inherent in oligosaccharide synthesis. The practical advantages of continuous-flow synthesis in microreactors (high reproducibility, easy scalability, and fast reaction optimization) may offer an effective support to make carbohydrates more attractive targets for drug-discovery processes. Here we report a systematic exploration of the glycosylation reaction carried out under microfluidic conditions. Trichloroacetimidates and thioglycosides have been investigated as glycosyl donors, using both primary and secondary acceptors. Each microfluidic glycosylation has been compared with the corresponding batch reaction, in order to highlight advantages and drawbacks of microreactors technology. As a significant example of multistep continuous-flow synthesis, we also describe the preparation of a trisaccharide by means of two consecutive glycosylations performed in interconnected microreactors.

Disaccharide-containing macrocycles by click chemistry and intramolecular glycosylation

Tiwari, Vinod K.,Kumar, Amit,Schmidt, Richard R.

, p. 2945 - 2956 (2012/07/27)

In this study o- and m-xylylene moieties in combination with a triazolylmethyl moiety have been successfully employed as a relatively rigid spacer system in intramolecular glycosylation reactions. Phenyl 3,4,6-tri-O-benzyl-2-O-propargyl-1-thio-D-glucopyra

Synthetic oligosaccharides as tools to demonstrate cross-reactivity between polysaccharide antigens

Pozsgay, Vince,Kubler-Kielb, Joanna,Coxon, Bruce,Santacroce, Paul,Robbins, John B.,Schneerson, Rachel

, p. 5922 - 5941 (2012/10/07)

Escherichia coli O148 is a nonencapsulated enterotoxigenic (ETEC) Gram negative bacterium that can cause diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome in humans. The surface-exposed O-specific polysaccharide (O-SP) of the lipopolysaccharide

Neighboring-group participation by C-2 ether functions in glycosylations directed by nitrile solvents

Chao, Chin-Sheng,Lin, Ching-Yu,Mulani, Shaheen,Hung, Wei-Cheng,Mong, Kwok-Kong Tony

supporting information; experimental part, p. 12193 - 12202 (2011/12/01)

Ether-protecting functions at C-2 hydroxy groups have been found to play participating roles in glycosylations when the reactions are conducted in nitrile solvent mixtures. The participation mechanism is based on intramolecular interaction between the lone electron pair of the oxygen atom of the C-2 ether function and the nitrile molecule when they are positioned in a cis configuration. A 1,2-cis glycosyl oxazolinium intermediate is formed. This participation, in conjunction with the anomeric effect of the glycosyl donor, confers high 1,2-trans selectivities on glycosylations. Further application of this concept has led to efficient preparations of α-(1→5)-arabinan oligomers.

1,2-Anhydrosaccharides and 1,2-cyclic sulfites as saccharide donors in convergent synthesis of glucopyranosyl-, mannopyranosyl- and ribofuranosylbenzocamalexin

Humenik, Martin,Kutschy, Peter,Kovacik, Vladimir,Bekesova, Slavka

, p. 487 - 506 (2007/10/03)

A convergent synthesis of 1-(β-o-glucopyranosyl)-, 1-(α-D-mannopyranosyl)- and 1-(β-D-ribofuranosyl) benzocamalexin was elaborated as an alternative route to the linear approach based on the indoline-indole method. 1,2-Anhydrosaccharides and 1,2-cyclic sulfites as saccharide donors were used in the key glycosylation step. Coupling with benzocamalexin resulted in moderate to excellent yields of nucleoside analogs, depending on the saccharide donor, catalyst and solvent used.

A convenient multigram preparation of functionalized 2-azido-2-deoxy-D-mannose as a useful orthogonally protected building block for oligosaccharide synthesis

Draghetti, Veronica,Poletti, Laura,Prosperi, Davide,Lay, Luigi

, p. 813 - 819 (2007/10/03)

Multigram preparation of strategically protected 2-azido-2-deoxy mannose 5 from pentaacetyl glucose 1 is described. This manno-derivative was obtained in a straightforward manner and in high overall yield and represents a flexible building-block for complex oligosaccharide synthesis.

Synthesis of the C-glycosidic analogue of adenophostin A and its uracil congener as potential IP3 receptor ligands. Stereoselective construction of the C-glycosidic structure by a temporary silicon-tethered radical coupling reaction

Abe, Hiroshi,Shuto, Satoshi,Matsuda, Akira

, p. 4315 - 4325 (2007/10/03)

Synthesis of the C-glycosidic analogue 9 of adenophostin A, a very potent IP3 receptor agonist, and its uracil congener 10 was achieved via a temporary silicon-tethered radical coupling reaction as the key step. Phenyl 3,4,6-tri-O-(p-methoxyben

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