147283-87-2

Basic information

• Product Name: methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate
• Synonyms: methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate
• CAS NO: 147283-87-2
• Molecular Weight: 298.24
• Mol File: 147283-87-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 330.1±42.0 °C(Predicted)
• Density: 1.464±0.06 g/cm3(Predicted)
• CAS DataBase Reference: methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate(147283-87-2)
• EPA Substance Registry System: methyl [3-[[(trifluoromethyl)sulfonyl]oxy]phenyl]-acetate(147283-87-2)

Safety Data

• Hazardous Substances Data: 147283-87-2(Hazardous Substances Data)

Usage

Uses

Methyl 3-((Trifluoromethylsulfonyl)oxy)phenylacetate is an intermediate in the synthesis of m-Isobutyl Ibuprofen (I780080). m-Isobutyl Ibuprofen (Ibuprofen EP Impurity A) is an Ibuprofen (I140000) impurity used in the study of potent noncompetitive interleukin-8 inhibitors.

Upstream product

• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 621-37-4 m-hydroxyphenylacetic acid 
• 67-56-1 methanol 

Downstream Products

• 52798-00-2 (3-cyano-phenyl)-acetic acid methyl ester 
• 1299295-04-7 methyl 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoate 
• 1299295-19-4 methyl 2-{3-[1-hex-1-en-1-yl]phenyl}propanoate 
• 1299295-05-8 2-(3-{[(trifluoromethyl)sulphonyl]oxy}phenyl)propanoic acid 
• 1299295-03-6 2-(3-{[3-methoxy-5-(trifluoromethyl)phenyl]amino}phenyl)propanoic acid 
• 1056455-02-7 [3-(2'-fluoro-4'-trifluoromethyl-biphenyl-3-sulfonyl)-phenyl]-acetic acid methyl ester 
• 71912-71-5 3-(2-hydroxy-1-ethyl)-1,1'-biphenyl 
• 597584-97-9 methyl 3-cyclobutyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate 
• 597584-91-3 methyl 2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]-3-phenylpropanoate 
• 597584-94-6 methyl 3-cyclopropyl-2-[4'-(4-methylpiperazin-1-yl)-1,1'-biphenyl-3-yl]propanoate 

Relevant articles and documents

2-ARYL-PROPIONAMIDE DERIVATIVES USEFUL AS BRADYKININ RECEPTOR ANTAGONISTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

(R,S) 2-aryl-propionamide derivatives, or their single enantiomers (R) and (S) are disclosed useful in the treatment or prevention of symptoms and disorders such as pain and inflammation associated with the bradykinin B 1 pathway.

PPAR active compounds

Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists. Part 2

A series of PPARδ-selective agonists was investigated and optimized for a favorable in vivo pharmacokinetic profile. Isoxazole LCI765 (17d) was found to be a potent and selective PPARδ agonist with good in vivo PK properties in mouse (Cmax = 5.1 μM, t1/2 = 3.1 h). LCI765 regulated expression of genes involved in energy homeostasis in relevant tissues when dosed orally in C57BL6 mice. A co-crystal structure of compound LCI765 and the LBD of PPARδ is discussed.