139481-28-0

Basic information

• Product Name: BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER
• Synonyms: BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER;Methyl,2-[[(2'-Cyano[1,1'-Biphenyl]-4-yl)methyl]amino]-3-Nitro Benzoate;4-yl)methyl]amino]-3-nitro-,methyl ester;Benzoic acid, 2-[[(2'-cyano[1,1'-biphenyl]-;methyl 2-((2'-cyanobiphenyl-4-yl)methylamino)-3-nitrobenzoate;2-[[(2'-Cyano[1,1'-biphenyl]-4-yl)Methyl]aMino]-3-nitro-benzoic Acid Methyl Ester
• CAS NO: 139481-28-0
• Molecular Formula: C₂₂H₁₇N₃O₄
• Molecular Weight: 387.38808
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 139481-28-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 595.483 °C at 760 mmHg
• Flash Point: 313.937 °C
• Appearance: /
• Density: 1.33±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• PKA: -2.55±0.10(Predicted)
• CAS DataBase Reference: BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER(139481-28-0)
• EPA Substance Registry System: BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER(139481-28-0)

Safety Data

• Hazardous Substances Data: 139481-28-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Different sources of media describe the Uses of 139481-28-0 differently. You can refer to the following data:
1. Intermediate in the synthesis of nonpeptide angiotensin II receptor antagonists. Candesartan (C175575) impurity. Candesartan Cilexetil (C175580) impurity.
2. Intermediate in the synthesis of nonpeptide angiotensin II receptor antagonists.

Upstream product

• 73833-13-3 acid chloride of 1-methylhydrogen-3-nitrophthalate 
• 603-11-2 3-nitrophthalic acid 
• 134-20-3 2-carbomethoxyaniline 
• 57113-90-3 methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 856414-36-3 2-Azidocarbonyl-3-nitro-benzoic acid methyl ester 
• 21606-04-2 methyl 2-carboxy-3-nitrobenzoate 
• 139481-38-2 methyl 2-amino>-3-nitrobenzoate 

Downstream Products

• 145040-37-5 candesartan cilexetil 
• 139481-72-4 2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid 
• 136304-78-4 methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate 
• 147403-52-9 methyl 2-ethoxy-1-[[2’-(2,5-dihydro-5-oxo-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 
• 139481-59-7 candesartan 
• 139482-06-7 3-[2'-(1H-Tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-(2,2,2-trifluoro-ethoxy)-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 139481-97-3 2-Morpholin-4-yl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 139481-98-4 2-Piperidin-1-yl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 139481-96-2 2-Butylamino-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid methyl ester 
• 136284-88-3 2-Ethylsulfanylmethyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid ethyl ester 
• 139481-71-3 2-Propylamino-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid ethyl ester 
• 139481-65-5 2-Propylsulfanyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid ethyl ester 
• 139481-60-0 ethyl 2-Propoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 
• 136285-07-9 Methyl 2-(2-methylthioethyl)-1-[[2'-(1H-tetrazol-5-yl]biphenyl-4-yl]methyl]benzimidazole-7-carboxylate 

Relevant articles and documents

PROCESS FOR PREPARATION OF CANDESART AN CILEXETIL SUBSTANTIALLY FREE OF DES-CANDESARTAN CILEXETIL IMPURITY

The present invention provides a process for preparation of candeartan cilexetil substantially free of 2,3-dihydro-2-oxo-3-[[2'-(2H-tetrazol-5-yl)[l,l-biphenyl]-4- yl]methyl]-l-[[(cyclohexyloxy)carbonyl]oxy]ethylester-lH-benzimidazole-7- carboxylate (des-candesartan cilexetil) impurity.

CRYSTAL AND PROCESS FOR PRODUCING THE SAME

A process for producing crystals of 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimdazole-7-carboxylic acid (compound (I)), characterized by dissolving or suspending the compound (I) or a salt thereof in a solvent comprising an aprotic polar solvent and crystallizing it. By the process, the contaminants which are contained in the compound (I) or its salt and are difficult to remove, such as tin compounds, analogues of the compound (I), and a residual organic solvent, can be easily removed. Crystals of the compound (I) can be efficiently and easily mass-produced in high yield on an industrial scale.