1515-84-0

Usage

Uses

Used in Organic Synthesis:
1-(MethoxyMethyl)-3-nitrobenzene is used as a reagent in organic synthesis for the methylation of various compounds. Its ability to transfer a methyl group makes it a key component in the creation of a wide range of organic products.
Used in Pharmaceutical Production:
As a key intermediate, 1-(MethoxyMethyl)-3-nitrobenzene is utilized in the production of pharmaceuticals. Its unique chemical structure contributes to the development of new drugs and medicines, enhancing the therapeutic options available.
Used in Agrochemical Production:
1-(MethoxyMethyl)-3-nitrobenzene also serves as an important intermediate in the creation of agrochemicals. Its role in this industry is crucial for the development of effective products for agricultural applications.
Used in the Development of New Materials:
1-(MethoxyMethyl)-3-nitrobenzene has been studied for its potential use in developing new materials. Its properties make it a promising candidate for contributing to advancements in material science.
Used as a Building Block in Diverse Organic Compounds Synthesis:
Recognized for its versatility, 1-(MethoxyMethyl)-3-nitrobenzene is used as a building block in the synthesis of a diverse array of organic compounds. Its chemical properties allow it to be a fundamental component in the creation of complex organic molecules for various applications across different industries.

Upstream product

• 619-25-0 3-Nitrobenzyl alcohol 
• 77-78-1 dimethyl sulfate 
• 538-86-3 benzyl methyl ether 
• 74-88-4 methyl iodide 
• 124-41-4 sodium methylate 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 67-56-1 methanol 
• 619-23-8 3-Nitrobenzyl chloride 
• 868-85-9 Dimethyl phosphite 
• 74-83-9 methyl bromide 

Downstream Products

• 53473-83-9 3-(1-methoxymethyl)phenylamine 
• 99-61-6 3-nitro-benzaldehyde 
• 618-95-1 methyl 3-nitrobenzoate 
• 98405-93-7 α-hydroperoxy-m-nitrobenzyl methyl ether 
• 1260095-61-1 N-(3-methoxymethylphenyl)-2,2-diphenylbenzo[d][1,3]dioxole-5-carboxamide 
• 1260095-65-5 N-(3-bromomethylphenyl)-3,4-dihydroxybenzamide 
• 1260095-69-9 4-tert-butyl-1-(3-(3,4-dihydroxybenzamido)benzyl)pyridinium bromide 

Relevant academic research and scientific papers

Liquid crystal aligning agent for photoalignment, liquid crystal alignment film and liquid crystal display device using it, and diamine and polymer

Provided are a liquid crystal alignment film capable of being given anisotropy through photoalignment and stable to light, and a liquid crystal display device capable of keeping a high voltage holding ratio without degradation of display quality even when

Efficient synthetic access to cationic dendrons and their application for ZnO nanoparticles surface functionalization: New building blocks for dye-sensitized solar cells

A new concept for the efficient synthesis of cationic dendrons, 4-tert-butyl-1-(3-(3,4-dihydroxybenzamido)benzyl)pyridinium bromide (17), 1,1′-(5-(3,4-dihydroxybenzamido)-1,3-phenylene)bis(methylene) bis(4-tert-butylpyridinium) bromide (18), N1,N7-bis(3-(

N-Phenyl-N′-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: Role of ω-hydroxyl group in the covalent binding to β-tubulin

Tubulin is the target of many anticancer drugs, including N-phenyl-N′-(2-chloroethyl)urea (CEU). Unlike most anti-β-tubulin agents, CEUs are protein monoalkylating agents binding through their N′-(2-chloroethyl)urea moiety to an amino acid nearby the colchicine-binding site on β-tubulin isoform-2. Following the previously synthesized and attractive N-(3-ω-hydroxyalkylphenyl)-N′-(2-chloroethyl)urea that exhibited growth inhibitory activity at the nanomolar level, we investigated the importance of lower alkyl and alkoxy groups to evaluate the effect of hydroxylated group and chain length on both cell growth inhibition and the mechanism of action of CEU. Here, we describe the preparation of two new series of CEU and show that the most potent CEU derivatives beside the ω-hydroxylated 1f were 2f and 3e, respectively. We have confirmed that the pentyl substituted CEUs 1f, 2f, and 3e are still covalently binding to β-tubulin and still arrest cell division in G2/M phase. Crown Copyright

Ozone-mediated nitration of phenylalkyl ethers, phenylacetic esters, and related compounds with nitrogen dioxide. the highest ortho substitution observed in the electrophilic nitration of arenes

By the combined action of ozonized oxygen and nitrogen dioxide (the kyodai-nitration), the title compounds were smoothly nitrated in dichloromethane at subzero degrees with hiigh ortho positional selectivity. Although the conventional nitration of phenylacetic acid and esters mainly produces m- and p-nitro derivatives, the present nitration offers a simple high-yield synthesis of o-nitro derivatives which are important as precursor in organic synthesis. The proportions of the ortho isomer in the nitration products from methyl 2-phenylethyl ether and methyl phenylacetate were 71 and 88%, respectively, the latter value being the highest ortho isomer proportion so far observed in the electrophilic aromatic nitration. The observed high ortho selectivity has been rationalized in terms of radical cation intermediate and six-membered cyclic transition state.

REACTIVITY OF THE ACIDS OF TRIVALENT PHOSPHORUS AND THEIR DERIVATIVES. PART IV. THE REACTION OF DIALKYLPHOSPHITE ANIONS WITH NITROBENZYL BROMIDES

The reaction of o-, m- and p-nitrobenzyl bromide with sodium dimethylphosphite as well as sodium diisopropylphosphite in THF and alcohols as the solvent is described.According to the constitution of the starting materials and the solvents used, the formation of the P-C bond, debromination or dimerization occurs.The principal process in o- and p-nitrobenzyl bromide and >P-O- anion systems is believed to be X-philic substitution, the dimer is formed through a secondary process via SET from the nitrobenzyl anion to nitrobenzyl bromide.Electron-transfer and proton-transfer processes in the nitrobenzyl bromide->P-O- systems are also discussed.Key words: o-, m- and p-nitrobenzyl bromides, dialkyl phosphites, Michaelis-Becker reaction, X-philic substitution, SET.

Photooxygenation of nitrobenzyl derivatives. Mechanism of photogeneration and hydrolysis of α-hydroperoxy nitrobenzyl ethers

The photooxygenation of nitrobenzyl derivatives 1-10 has been studied in aqueous solution as a function of pH.For m-nitrobenzyl ethers 2-4 and 9, stable α-hydroperoxy ethers (11-13) are the primary photochemical products.Acid hydrolysis of 11-13 gives m-nitrobenzaldehyde and hydrogen peroxide.Quantum yields for photooxygenation are reported for a number of derivatives as a function of pH.Acid and base catalyses of photooxygenation are observed for several compounds.A mechanism involving photogenerated nitrobenzyl carbanion intermediates is proposed.

N-Alkyl-N-[3-(alkoxyalkyl)phenyl]-2-haloacetamide herbicides

This invention concerns certain N-alkyl-N-[3-(alkoxyalkyl)phenyl]-2-haloacetamides having herbicidal activity, their preparation, and the control of weeds therewith.