6186-86-3

Basic information

• Product Name: 4-hydroxynaphthalen-1-yl thiocyanate
• CAS NO: 6186-86-3
• Molecular Formula: C₁₁H₇NOS
• Molecular Weight: 201.2444
• Mol File: 6186-86-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 417.4°C at 760 mmHg
• Flash Point: 206.2°C
• Density: 1.38g/cm³
• Vapor Pressure: 1.47E-07mmHg at 25°C
• Refractive Index: 1.735
• CAS DataBase Reference: 4-hydroxynaphthalen-1-yl thiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxynaphthalen-1-yl thiocyanate(6186-86-3)
• EPA Substance Registry System: 4-hydroxynaphthalen-1-yl thiocyanate(6186-86-3)

Safety Data

• Hazardous Substances Data: 6186-86-3(Hazardous Substances Data)

Upstream product

• 505-14-6 thiocyanogen 
• 90-15-3 α-naphthol 
• 333-20-0 potassium thioacyanate 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 1147550-11-5 ammonium thiocyanate 
• 592-87-0 lead(II) thiocyanate 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 67-56-1 methanol 
• 36942-09-3 N,N-dichlorourea 
• 15192-76-4 copper(II) thiocyanate 
• 60763-20-4 selenium dithiocyanate 

Relevant articles and documents

N -Thiocyanato-dibenzenesulfonimide: A new electrophilic thiocyanating reagent with enhanced reactivity

A novel electrophilic thiocyanating reagent, N-thiocyanato-dibenzenesulfonimide, was prepared and exhibited enhanced electrophilicity with a wide scope of substrates. Thus, it reacted with activated aromatics such as phenols, indoles, anilines and anisoles without a catalyst giving the corresponding thicyanate derivatives in high yields, while TfOH for unactivated arenes and hetero aromatics and Zn(OTf)2 for ketones was used as the catalyst, respectively. It is noteworthy that internal alkenes and styrenes were bifunctionalized giving 1,2-amino thiocyanates in high yields.

Oxidant-free thiocyanation of phenols and carbonyl compounds under solvent-free conditions by AlCl 3/NH 4SCN

A simple, efficient, solvent-free, and mild method for thiocyanation of phenols by ammonium thiocyanate (NH4SCN) in the presence of AlCl3 has been developed. This new methodology was used to prepare para-thiocyanated products in good to excellent yields at 70°C. In addition, the successful α-thiocyanation of various ketones has also been described. Finally, a plausible mechanism of thiocyanation has been suggested.

Compounds that modulate PPAR activity and methods of preparation

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.