93-85-6

Basic information

• Product Name: 2-Aminobenzothiazole-6-carboxylic acid
• Synonyms: 2-Amino-benzothiazole-6-carboxylic acid hydrochloride;SALOR-INT L481106-1EA;6-BENZOTHIAZOLECARBOXYLIC ACID, 2-AMINO-;AKOS BB-7723;AKOS BBS-00000327;2-AMINO-1,3-BENZOTHIAZOLE-6-CARBOXYLIC ACID;2-AMINO-6-BENZOTHIAZOLECARBOXYLIC ACID;2-AMINO-BENZOTHIAZOLE-6-CARBOXYLIC ACID
• CAS NO: 93-85-6
• Molecular Formula: C₈H₆N₂O₂S
• Molecular Weight: 194.21
• EINECS: 202-283-8
• Product Categories: Heterocycles;BENZOTHIAZOLE
• Mol File: 93-85-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 265 ºC (DEC.)
• Boiling Point: 466.6 °C at 760 mmHg
• Flash Point: 236 °C
• Appearance: /
• Density: 1.604
• Vapor Pressure: 1.65E-09mmHg at 25°C
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.99±0.30(Predicted)
• CAS DataBase Reference: 2-Aminobenzothiazole-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminobenzothiazole-6-carboxylic acid(93-85-6)
• EPA Substance Registry System: 2-Aminobenzothiazole-6-carboxylic acid(93-85-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 93-85-6(Hazardous Substances Data)

Usage

Chemical Properties

Light brown powder

InChI:InChI=1/C8H6N2O2S/c9-8-10-5-2-1-4(7(11)12)3-6(5)13-8/h1-3H,(H2,9,10)(H,11,12)/p-1

Synthetic route

potassium thioacyanate (333-20-0) + 4-amino-benzoic acid (150-13-0) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With sodium iodide dichloride at 70℃; for 10h;	97%
With bromine In acetic acid for 2h;	68%
Stage #1: potassium thioacyanate; 4-amino-benzoic acid With bromine In methanol Stage #2: With hydrogenchloride In methanol

4-amino-3-thiocyanatobenzonitrile (68867-21-0) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With hydrogenchloride; water at 100℃; for 6h;	59%
With hydrogenchloride; water at 100℃; for 6h;	59%
With hydrogenchloride In water at 100℃; for 6h;	59%

sodium thiocyanide (540-72-7) + 4-amino-benzoic acid (150-13-0) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With bromine In methanol at -10 - -5℃; for 2h;	42%

2-aminobenzo[d]thiazole-6-carboxylic acid methyl ester (66947-92-0) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With sodium hydroxide In ethanol at 20℃; for 4h;	33%

N-(6-methylbenzo[d]thiazol-2-yl)acetamide (20600-51-5) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With potassium permanganate; water; magnesium sulfate Erwaermen des Reaktionsprodukts mit wss. H2SO4;

ethyl 2-aminobenzothiazole-6-carboxylate (50850-93-6) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With hydrogenchloride
With hydrogenchloride Heating;
With LiOH In 1,4-dioxane; water
With LiOH In 1,4-dioxane; water

ammonium thiocyanate (1147550-11-5) + 4-amino-benzoic acid (150-13-0) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With bromine; acetic acid Erhitzen des Reaktionsprodukts mit wss. HCl;

copper(II) thiocyanate (15192-76-4) + 4-amino-benzoic acid (150-13-0) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With acetic acid

6-methylbenzothiazol-2-ylamine (2536-91-6) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
Multi-step reaction with 2 steps 2: KMnO4; MgSO4; H2O / Erwaermen des Reaktionsprodukts mit wss. H2SO4 View Scheme

4-thioureidobenzoic acid ethyl ester (23051-16-3) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine; chloroform / Behandeln des Reaktionsprodukts mit schwefliger Saeure 2: hydrochloric acid View Scheme

p-aminoethylbenzoate (94-09-7) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: (i) Br2, AcOH, (ii) aq. Na2CO3 2: aq. HCl / Heating View Scheme

ammonium thiocyanate + 4-amino-benzoic acid (150-13-0) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With sodium hydroxide; bromine In water; acetic acid

4-amino-benzoic acid (150-13-0) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: bromine; acetic acid / water / 0 - 10 °C 2: hydrogenchloride / water / 2 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: bromine / acetic acid / 1 h / 0 - 10 °C 2: hydrogenchloride; water / 2 h / Reflux View Scheme

4-Aminobenzonitrile (873-74-5) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid / 3.5 h / 20 °C / Cooling with ice 2: hydrogenchloride; water / 6 h / 100 °C View Scheme
Multi-step reaction with 2 steps 1: acetic acid; bromine / 3.5 h / 20 °C / Cooling with ice 2: hydrogenchloride / water / 6 h / 100 °C View Scheme

4-amino-3-thiocyanatobenzoic acid (18330-64-8) → 2-aminobenzothiazole-6-carboxylic acid (93-85-6)

Conditions	Yield
With hydrogenchloride In water for 2h; Reflux;
With hydrogenchloride; water for 2h; Reflux;

2-aminobenzothiazole-6-carboxylic acid (93-85-6) → 4-amino-3-mercaptobenzoic acid zinc salt

Conditions	Yield
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With potassium hydroxide; water for 3h; Heating / reflux; Stage #2: With hydrogenchloride In water at 20℃; Stage #3: With zinc(II) chloride In water	98%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + benzylamine (100-46-9) → 2-amino-N-benzylbenzo[d]thiazole-6-carboxamide

Conditions	Yield
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide for 0.0333333h; Stage #2: benzylamine In N,N-dimethyl-formamide at 20℃; for 18h;	88%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	65%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + C15H11BrCl2OS (1280582-87-7) → 2-(2,4-dichlorophenyl)-3-[4-(methylsulfanyl)phenyl]imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid (1370023-99-6)

Conditions	Yield
In ethanol Reflux;	85.67%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H11BrCl2OS In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	85.67%

2-bromo-1,2-bis(4-methoxyphenyl)ethanone (27895-95-0) + 2-aminobenzothiazole-6-carboxylic acid (93-85-6) → 2,3-bis(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid (1280582-32-2)

Conditions	Yield
In ethanol Reflux;	83.55%
Stage #1: 2-bromo-1,2-bis(4-methoxyphenyl)ethanone; 2-aminobenzothiazole-6-carboxylic acid In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	83.55%

2-bromo-1-(4''-(methylthio)phenyl)-2-(4'-methoxyphenyl)-1-ethanone + 2-aminobenzothiazole-6-carboxylic acid (93-85-6) → 2-(4-methoxyphenyl)-3-[4-(methylsulfanyl) phenyl]imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid (1370409-52-1)

Conditions	Yield
In ethanol Reflux;	82.9%
Stage #1: 2-bromo-1-(4''-(methylthio)phenyl)-2-(4'-methoxyphenyl)-1-ethanone; 2-aminobenzothiazole-6-carboxylic acid In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	82.9%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + chloroacetyl chloride (79-04-9) → 2-(2-chloroacetylamino)benzothiazole-6-carboxylic acid

Conditions	Yield
With potassium carbonate In chloroform for 12h; Heating;	81%

isonipecotic acid methyl ester (2971-79-1) + 2-aminobenzothiazole-6-carboxylic acid (93-85-6) → methyl 1-(2-aminobenzo[d]thiazole-6-carbonyl)piperidine-4-carboxylate

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	81%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + C15H12BrClO2 (1280582-79-7) → 2-(2-chlorophenyl)-3-(4-methoxyphenyl)-2,3-dihydroimidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid (1370409-59-8)

Conditions	Yield
In ethanol Reflux;	78.29%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H12BrClO2 In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	78.29%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + acetic anhydride (108-24-7) → 2-acetamidobenzo[d]thiazole-6-carboxylic acid (100817-94-5)

Conditions	Yield
With pyridine for 2h; Heating;	76%

methanol (67-56-1) + 2-aminobenzothiazole-6-carboxylic acid (93-85-6) → 2-aminobenzo[d]thiazole-6-carboxylic acid methyl ester (66947-92-0)

Conditions	Yield
With dmap; diazomethyl-trimethyl-silane In tetrahydrofuran; hexane at 20℃;	75%
sulfuric acid

3,4,5-trimethoxybenzylamine (18638-99-8) + 2-aminobenzothiazole-6-carboxylic acid (93-85-6) → 2-amino-N-(3,4,5-trimethoxybenzyl)benzo[d]thiazole-6-carboxamide

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	74%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + C15H12BrClOS (1280582-80-0) → 2-(2-chlorophenyl)-3-[4-(methylsulfanyl) phenyl]-2,3-dihydroimidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid (1370025-25-4)

Conditions	Yield
In ethanol Reflux;	72.6%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H12BrClOS In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	72.6%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + 2-(aminomethyl)-5-((4-methoxybenzyl)oxy)-4H-pyran-4-one → 2-amino-N-((5-((4-methoxybenzyl)oxy)-4-oxo-4H-pyran-2-yl)methyl)benzo[d]thiazole-6-carboxamide

Conditions	Yield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;	72.4%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + isopropyl alcohol (67-63-0) → isopropyl 2-aminobenzo[d]thiazole-6-carboxylate (134949-38-5)

Conditions	Yield
With sulfuric acid at 0℃; for 24h; Reflux;	71%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + Benzhydrylamine (91-00-9) → 2-amino-N-benzhydrylbenzo[d]thiazole-6-carboxamide

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	70%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) → 4-amino-3-mercaptobenzoic acid (14543-45-4)

Conditions	Yield
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With water; potassium hydroxide for 24h; Inert atmosphere; Reflux; Stage #2: With hydrogenchloride In water Cooling with ice;	67.9%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With water; potassium hydroxide for 24h; Inert atmosphere; Reflux; Stage #2: With hydrogenchloride In water Cooling with ice;	67.9%
With potassium hydroxide In water for 24h; Inert atmosphere; Reflux;	67.9%
With water; potassium hydroxide for 3h; Reflux;	66.1%
With potassium hydroxide In water

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + C15H11BrCl2O (1280582-84-4) → 2-(2,4-dichlorophenyl)-3-(4-methylphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid (1370024-36-4)

Conditions	Yield
In ethanol Reflux;	66.3%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H11BrCl2O In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	66.3%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + C15H11BrCl2O2 (1280582-86-6) → 2-(2,4-dichlorophenyl)-3-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid (1370409-53-2)

Conditions	Yield
In ethanol Reflux;	65.46%
Stage #1: 2-aminobenzothiazole-6-carboxylic acid; C15H11BrCl2O2 In ethanol Reflux; Stage #2: With phosphorus pentoxide In ethanol Reflux;	65.46%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + 3-[methyl(phenyl)amino]propyl acetate → 2-[(E)-(4-{[3-(acetyloxy)propyl](methyl)amino}phenyl)diazenyl]-1,3-benzothiazole-6-carboxylic acid

Conditions	Yield
Stage #1: 2-aminobenzothiazole-6-carboxylic acid With nitrosylsulfuric acid In acetic acid; propionic acid at 0 - 20℃; for 4.08333h; Stage #2: 3-[methyl(phenyl)amino]propyl acetate With aminosulfonic acid In methanol; water; acetic acid; propionic acid at 0 - 4℃; for 1.08333h;	64%

7‐(4‐bromobutoxy)‐5‐hydroxy‐2‐phenyl‐4H‐chromen‐4‐one (873302-27-3) + 2-aminobenzothiazole-6-carboxylic acid (93-85-6) → 2-(4-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)butylamino)benzo[d]thiazole-6-carboxylic acid

Conditions	Yield
In acetonitrile Reflux;	61%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + 3,4-dichlorobenzyl amine (102-49-8) → 2-amino-N-(3,4-dichlorobenzyl)benzo[d]thiazole-6-carboxamide

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	61%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + benzyl bromide (100-39-0) → benzyl 2-aminobenzo[d]thiazole-6-carboxylate

Conditions	Yield
In acetonitrile at 20℃; for 18h;	61%

tryptamine (61-54-1) + 2-aminobenzothiazole-6-carboxylic acid (93-85-6) → N-(2-(1H-indol-3-yl)ethyl)-2-aminobenzo[d]thiazole-6-carboxamide

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	59%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + 2ClH*C6H7NO → 6-(benzo[d]oxazol-2-yl)benzo[d]thiazol-2-amine

Conditions	Yield
With Eaton′s Reagent for 8h; Reflux;	56%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → 4-(4-methoxyphenyl)-7-thia-2,5-diazatricyclo[6.4.0.02,6] dodeca-1(8),3,5,9,11-pentaene-10-carboxylic acid

Conditions	Yield
In 2-methoxy-ethanol at 40 - 140℃; for 43h;	55%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + methyl 4-(aminomethyl)benzoate (18469-52-8) → methyl 4-((2-aminobenzo[d]thiazole-6-carboxamido)methyl)benzoate

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 24h;	53%

2-aminobenzothiazole-6-carboxylic acid (93-85-6) + tert–butyl (2–aminophenyl)carbamate (146651-75-4) → {2-[(2-amino-benzothiazole-6-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester (866000-85-3)

Conditions	Yield
With BOP; triethylamine In DMF (N,N-dimethyl-formamide) at 20℃;	52%

Upstream product

• 20600-51-5 N-(6-methylbenzo[d]thiazol-2-yl)acetamide 
• 50850-93-6 ethyl 2-aminobenzothiazole-6-carboxylate 
• 1147550-11-5 ammonium thiocyanate 
• 150-13-0 4-amino-benzoic acid 
• 15192-76-4 copper(II) thiocyanate 
• 333-20-0 potassium thioacyanate 
• 66947-92-0 2-aminobenzo[d]thiazole-6-carboxylic acid methyl ester 
• 18330-64-8 4-amino-3-thiocyanatobenzoic acid 
• 2536-91-6 6-methylbenzothiazol-2-ylamine 
• 68867-21-0 4-amino-3-thiocyanatobenzonitrile 
• 873-74-5 4-Aminobenzonitrile 
• 540-72-7 sodium thiocyanide 
• 94-09-7 p-aminoethylbenzoate 
• 23051-16-3 4-thioureidobenzoic acid ethyl ester 

Downstream Products

• 117342-15-1 2-hydrazino-benzothiazole-6-carboxylic acid 
• 50850-93-6 ethyl 2-aminobenzothiazole-6-carboxylate 
• 866000-85-3 {2-[(2-amino-benzothiazole-6-carbonyl)-amino]-phenyl}-carbamic acid tert-butyl ester 
• 1191251-75-8 2-(4-nitrophenyl)imidazo[2,1-b][1,3]benzothiazol-7-carboxylic acid 
• 99615-68-6 2-oxo-2,3-dihydro-1,3-benzothiazole-6-carboxylic acid 
• 1370024-75-1 2-(2-chlorophenyl)-3-(4-methylphenyl)-2,3-dihydroimidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid 
• 1370025-25-4 2-(2-chlorophenyl)-3-[4-(methylsulfanyl) phenyl]-2,3-dihydroimidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid 
• 1370024-36-4 2-(2,4-dichlorophenyl)-3-(4-methylphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid 
• 1370409-53-2 2-(2,4-dichlorophenyl)-3-(4-methoxyphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid 
• 1370023-99-6 2-(2,4-dichlorophenyl)-3-[4-(methylsulfanyl)phenyl]imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid 
• 1370024-54-6 2-(4-methoxyphenyl)-3-(4-methylphenyl)imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid 
• 1053936-80-3 C₂₄H₁₆N₂O₆S₂ 
• 1054502-27-0 C₂₄H₁₆N₂O₇S 
• 1055126-64-1 C₂₃H₁₄N₂O₆S 

Relevant articles and documents

An efficient one-pot synthesis of 2-aminobenzothiazoles from substituted anilines using benzyltrimethylammonium dichloroiodate and ammonium thiocyanate in DMSO:H2O

Treatment of a variety of substituted anilines with benzyltrimethylammonium dichloroiodate (1.2 equiv) and ammonium thiocyanate (1.0 equiv) in DMSO:H2O (9:1) at 70 °C gave the corresponding 2-aminobenzothiazoles in excellent isolated yields (75–97%; ave. yield for all substrates = 90%). The reaction worked well for 2(4)-mono-, 2,4-di-, or 3,4,5-tri-substituted anilines, and a wide range of both electron donating groups (MeO, HO, CF3O, Me) and electron withdrawing groups (NO2, CN, CO2Et, CO2H, Cl, F) were well tolerated. This method provides a useful alternative to other methods that are either less efficient (requiring 3–7 fold equivalents of reagents) or utilize highly toxic and corrosive liquid Br2 as the oxidizing agent.

Dye compounds

The present invention relates to dye compounds represented by Formulae I and II, which are described in the specification. The dye compounds of the present invention have markedly improved quantum yields and emit strong fluorescence compared to existing cyanine dyes. Due to these advantages, the dye compounds of the present invention can find applications in various fields, for example, as probes for various biological systems where optical imaging is required. Particularly, the dye compounds of the present invention can be used as mitotrackers capable of labeling and tracking mitochondria. Therefore, the dye compounds of the present invention can be used to quantitatively image mitochondria in live tissues and cells. Furthermore, the dye compounds of the present invention can be applied as pH probes for measuring the pH of live cells.

Chrysin-benzothiazole conjugates as antioxidant and anticancer agents

7-(4-Bromobutoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one, obtained from chrysin with 1,4-dibromobutane, was combined with a wide range of 6-substituted 2-aminobenzthiazoles, which had been prepared from the corresponding anilines with potassium thiocyanate. Free radical scavenging efficacies of newer analogues were measured using DPPH and ABTS assays, in addition to the assessment of their anticancer activity against cervical cancer cell lines (HeLa and CaSki) and ovarian cancer cell line (SK-OV-3) implementing the SRB assay. Cytotoxicity of titled compounds was checked using Madin-Darby canine kidney (MDCK) non-cancer cell line. Overall, 6a-r indicated remarkable antioxidant power as DPPH and ABTS+ scavengers; particularly the presence of halogen(s) (6g, 6h, 6j-6l) was favourable with IC50 values comparable to the control ascorbic acid. Unsubstituted benzothiazole ring favored the activity of resultant compounds (6a and 6r) against HeLa cell line, whereas presence of chlorine (6g) or a di-fluoro group (6k) was a key to exert strong action against CaSki. Moreover, a mono-fluoro (6j) and a ketonic functionality (6o) were beneficial to display anticipated anticancer effects against ovarian cancer cell line SK-OV-3. The structural assignments of the new products were done on the basis of IR, 1H NMR, 13C NMR spectroscopy and elemental analysis.