15222-36-3Relevant academic research and scientific papers
Green Access to α-Haloalkyl and α-Halobenzyl Esters, Versatile Intermediates for the One-Pot Two-Step Synthesis of O, O ′-Diacyl Acetals Using Zinc-Based Ionic Liquid Catalyst
Fache, Fabienne,De Azpiazu, Ignasi,Pelotier, Béatrice,Piva, Olivier,Gozzi, Christel
, p. 2430 - 2434 (2019/05/27)
α-Haloalkyl and α-halobenzyl esters have been synthesized using a zinc-based ionic liquid catalyst, BMIZnCl 3. These esters can then react with acids without intermediate purification to obtain mixed O, O ′-diacyl acetals in a one-pot process.
Huperzine a prodrugs and uses thereof
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Page/Page column 13, (2008/06/13)
Disclosed are huperzine A prodrugs and method of synthesis thereof. The invention further relates to methods of treating, preventing or reversing neurodegenerative diseases, such as, Alzheimer's Disease and neuronal dysfunctions, such as, memory impairment using a pharmaceutical composition comprising a huperzine A prodrug as disclosed herein.
Zn(OTf)2.6H2O catalysed acylation of aldehydes: Preparation of 1,1-diacetates and α-chloroalkyl esters
Su, Weike,Can, Jin
, p. 88 - 90 (2007/10/03)
1,1-Diacetates (acylals) and α-chloroalkyl esters were prepared from carbonyl compounds with acylating reagents in the presence of 5% mol hexaaqua zinc triflate [Zn(OTf)2.6H2O] with good yields under mild reaction conditions.
Electrophilic reactions of carboyl compounds and derivatives thereof: XIII preparation of bifunctional compounds from aldehydes and olefins by acylation under acidic catalysis
Luk'yanov,Koblik,Murad'yan
, p. 1593 - 1599 (2007/10/03)
The reactions of aldehydes and their O-acylated derivatives (α-chloroesters, acylals) with olefins and α-ethoxystyrene in the presence of SnCl4 and ZnCl2 were investigated. The reactions afforded various bifunctional derivatives: diols, hydroxyesters, chloroesters, 1,3-ketoalcohols.
N-heteroarylium Salts in Synthesis, 3 Intramolecular ortho-Acylation of Some N-Heteroaromatic Ring Systems
Anders, Ernst,Boldt, Hans Guenter,Clark, Timothy,Fuchs, Renate,Gassner, Thomas
, p. 279 - 296 (2007/10/02)
The title compounds 17 (prepared by methods A-C) have been reacted with sodium bis(trimethylsilyl)amide (18) in a heterogeneous mixture (-80 deg C, 2-60 h).The ortho-substituted N-heteroaromatic compounds 4 are isolated exclusively after an intramolecular and regiospecific reaction .This method represents the first widely applicable acylation technique for N-heteroaromatic compounds in which the incoming substituent (R1CO) functions as an internal electrophile and in which the formation of isomeric or polyacylated products has not yet been observed.Both experimental and theoretical (MNDO) investigations show that the substitution reaction (5) is primarily determined by the conformational and electronic properties of the deprotonation product 25 , which is formed preferentially.
phosphonium Salts, 4: Synthetic Methods
Anders, Ernst,Gassner, Thomas,Stankowiak, Achim
, p. 124 - 131 (2007/10/02)
Four syntheses A - D are described for the phosphonium salts 1, which are precursors of the highly reactive phosphoranes 3.Whereas the usual method B fails in some cases it is now possible to prepare 1 with a wide variety of substituents R1, R
