154320-48-6Relevant articles and documents
Efficient palladium-catalyzed synthesis of 2-aryl propionic acids
Neumann, Helfried,Sergeev, Alexey G.,Spannenberg, Anke,Beller, Matthias
, (2020/09/16)
A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps.
Palladium-catalyzed α-arylation of zinc enolates of esters: Reaction conditions and substrate scope
Hama, Takuo,Ge, Shaozhong,Hartwig, John F.
, p. 8250 - 8266 (2013/09/24)
The intermolecular α-arylation of esters by palladium-catalyzed coupling of aryl bromides with zinc enolates of esters is reported. Reactions of three different types of zinc enolates have been developed. α-Arylation of esters occurs in high yields with i
Substituted Spiro Compounds and Their Use for Producing Pain-Relief Medicaments
-
, (2008/12/04)
The present invention relates to substituted spiro compounds, to processes for preparing them, to medicaments comprising these compounds and to the use of these compounds for producing medicaments.
