(+/-)-2-(4-tert-butylphenyl)propionic acid methyl ester

Base Information

• Chemical Name: (+/-)-2-(4-tert-butylphenyl)propionic acid methyl ester
• CAS No.: 154320-48-6
• Molecular Formula: C₁₄H₂₀O₂
• Molecular Weight: 220.312
• Mol file: 154320-48-6.mol

Synonyms:(+/-)-2-(4-tert-butylphenyl)propionic acid methyl ester

Chemical Property of (+/-)-2-(4-tert-butylphenyl)propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-(4-tert-butylphenyl)propionic acid methyl ester

There total 9 articles about (+/-)-2-(4-tert-butylphenyl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 4-tert-Butylstyrene (1746-23-2,26009-55-2) → 3-(4-tert-butyl-phenyl)propionic acid methyl ester (1211-99-0) + (+/-)-2-(4-tert-butylphenyl)propionic acid methyl ester (154320-48-6)

Guidance literature:

With 5-chloro-2-hydroxybenzoic acid; boric acid; Tri(p-tolyl)phosphine; palladium diacetate; for 24h; under 25857.4 Torr; Heating;

DOI:10.1021/ol062646n

Reference yield: 89.0%

methyl 2-(4-tert-butylphenyl)acetate (3549-23-3) + methyl iodide (74-88-4) → (+/-)-2-(4-tert-butylphenyl)propionic acid methyl ester (154320-48-6)

Guidance literature:

methyl 2-(4-tert-butylphenyl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -70 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; at -70 - 20 ℃; for 16.0833h;

Reference yield: 86.0%

propanoic acid methyl ester (554-12-1) + 1-bromo-4-tert-butylbenzene (3972-65-4) → (+/-)-2-(4-tert-butylphenyl)propionic acid methyl ester (154320-48-6)

Guidance literature:

propanoic acid methyl ester; With sodium hexamethyldisilazane; In toluene; at -60 ℃; for 1.5h; Inert atmosphere; Sealed tube;

With zinc(II) chloride; In tetrahydrofuran; toluene; at -35 ℃; for 1h; Inert atmosphere; Sealed tube;

1-bromo-4-tert-butylbenzene; With monophosphine 1,2,3,4,5-pentaphenyl-1'-(di-tert-butylphosphino)ferrocene; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; toluene; at -15 - 20 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1021/jo401476f

upstream raw materials:

methyl 2-(4-tert-butylphenyl)acetate

methyl iodide

methanol

carbon monoxide

Downstream raw materials:

2-(4-tert-butylphenyl)propionic acid

(+/-)-2-[1-(4-tert-butylphenyl)ethyl]-3-methyl-[1,4]naphthoquinone

2-(4-t-butylphenyl)propionamide

2-(4-t-butylphenyl)propylamine