15573-67-8

Basic information

• Product Name: 4-Hydroxyphenylglyoxylic acid
• Synonyms: 4-Hydroxyphenylglyoxylic acid
• CAS NO: 15573-67-8
• Molecular Formula: C₈H₆O₄
• Molecular Weight: 166.13084
• EINECS: 259-205-0
• Mol File: 15573-67-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 358.9°Cat760mmHg
• Flash Point: 185°C
• Appearance: /
• Density: 1.457g/cm³
• Vapor Pressure: 8.95E-06mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Hydroxyphenylglyoxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxyphenylglyoxylic acid(15573-67-8)
• EPA Substance Registry System: 4-Hydroxyphenylglyoxylic acid(15573-67-8)

Safety Data

• Hazardous Substances Data: 15573-67-8(Hazardous Substances Data)

Usage

General Description

4-Hydroxyphenylglyoxylic acid is a chemical compound with the molecular formula C8H6O4. It is a derivative of phenylglyoxylic acid and contains a hydroxyl group attached to the phenyl ring. 4-Hydroxyphenylglyoxylic acid has been studied for its potential biological properties, including its ability to act as an inhibitor of enzymes involved in the biosynthesis of neurotransmitters, such as tyrosine hydroxylase and phenylalanine hydroxylase. Additionally, 4-Hydroxyphenylglyoxylic acid has been investigated for its potential application in the synthesis of pharmaceutical compounds and as a building block for organic synthesis. It is also used as a building block for dyes, drugs, agrochemicals, and fine chemicals.

InChI:InChI=1/C8H6O4.Na/c9-6-3-1-5(2-4-6)7(10)8(11)12;/h1-4,9H,(H,11,12);/q;+1/p-1

Upstream product

• 2628-17-3 4-Vinylphenol 
• 99-93-4 4-Hydroxyacetophenone 
• 26787-78-0 amoxicillin 
• 70080-54-5 4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester 
• 6324-01-2 p-hydroxyphenylglycine 
• 37763-23-8 D-2-p-hydroxyphenylglycine methyl ester 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 38250-16-7 4-hydroxy-alpha-oxobenzeneacetic acid methyl ester 
• 13244-75-2 (S)-α,4-dihydroxy-benzeneacetic acid 
• 7664-93-9 sulfuric acid 
• 15535-99-6 4-amino-α-oxophenylacetic acid 
• 75318-43-3 4,5-dichloro-1,2,3-dithiazolium chloride 
• 108-95-2 phenol 
• 76590-59-5 4-(4-Hydroxy-phenyl)-2-trifluoromethyl-4H-oxazol-5-one 

Downstream Products

• 1036242-16-6 C₂₂H₁₇N₃O₃ 
• 1137-42-4 4-Hydroxybenzophenone 
• 6324-01-2 p-hydroxyphenylglycine 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 34917-91-4 4-hydroxyisobutyrophenone 
• 66340-55-4 (4-Hydroxy-phenyl)-[(Z)-methoxyimino]-acetic acid methyl ester 
• 840-81-3 (E)-N’-(4'-hydroxybenzylidene)isonicotinohydrazide 
• 13244-78-5 (R)-α,4-dihydroxy-benzeneacetic acid 
• 13244-75-2 (S)-α,4-dihydroxy-benzeneacetic acid 

Relevant articles and documents

ONE-STEP SYNTHESIS OF α-HYDROXY ACIDS VIA REDUCTIVE DOUBLE CARBONYLATION OF ORGANIC HALIDES

Palladium-catalyzed carbonylation of organic halides with water in the presence of calcium hydroxide or lithium hydroxide in primary or secondary alcoholic solvents afforded α-hydroxy acids.

A COMPOUND FOR THE DETERMINATION OF THE PROTEIN FKBP12 AND A SENSOR UNIT COMPRISING IT

The present invention relates to novel compounds useful as sensors for the rapid and specific determination of the FKBP12 protein, a peptidyl-prolyl cis-trans isomerase (PPlase), the levels of which in the biological fluids of a subject change if the subject is affected by pathological conditions, in particular neurodegenerative diseases, such as the Parkinson's disease and the Alzheimer's syndrome, tumour pathologies, autoimmune diseases, or if that subject is in a phase of acute rejection after organ transplantation.

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

Synthesis of arylglyoxylic acids and their collision-induced dissociation

A variety of substituted arylglyoxylic acids (2a-g) were synthesized via oxidation of the corresponding aryl-methylketones (1a-e) using selenium dioxide or Friedel-Crafts acylation of phenol (3) with ethyl chlorooxoacetate and further transformations. It was found that the arylglyoxylic acids (2) undergo facile unimolecular dissociation with loss of carbon monoxide to give the corresponding arylcarboxylic acids (7) under collisionally induced mass spectrometric conditions. Copyright Taylor & Francis Group, LLC.