156017-44-6

Basic information

• Product Name: L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-N-[(9H-fluoren-9-ylmethoxy)carb onyl]-, methyl ester
• CAS NO: 156017-44-6
• Molecular Formula: C30H32F2NO7P
• Molecular Weight: 587.557
• Mol File: 156017-44-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-N-[(9H-fluoren-9-ylmethoxy)carb onyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-N-[(9H-fluoren-9-ylmethoxy)carb onyl]-, methyl ester(156017-44-6)
• EPA Substance Registry System: L-Phenylalanine, 4-[(diethoxyphosphinyl)difluoromethyl]-N-[(9H-fluoren-9-ylmethoxy)carb onyl]-, methyl ester(156017-44-6)

Safety Data

• Hazardous Substances Data: 156017-44-6(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 1991-81-7 4-iodo-L-phenylalanine 
• 113850-77-4 (S)-methyl 2-amino-3-(4-iodophenyl)propanoate 
• 1711-02-0 4-iodobenzoic acid chloride 
• 229962-91-8 methyl (2S)-2-(((9H-fluoren-9-ylmethoxy)carbonyl)amino)-3-(((4-methylbenzene)sulfonyl)oxy)propanoate 
• 156017-40-2 diethyl (4-iodobenzoyl)phosphonate 
• 82911-78-2 N-[(9-fluorenylmethoxy)carbonyl]-L-serine methyl ester 
• 82565-68-2 N-fmoc-4-iodo-(L)-phenylalanine 
• 65094-22-6 diethyl (bromodifluoromethyl)phosphonate 
• 195258-67-4 (S)-methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-iodophenyl)propanoate 
• 156017-41-3 [Difluoro-(4-iodo-phenyl)-methyl]-phosphonic acid diethyl ester 
• 156017-42-4 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-iodo-propionic acid methyl ester 

Downstream Products

• 932725-90-1 C₄₇H₅₉Cl₂F₄N₇O₁₅P₂ 
• 880596-78-1 C₃₅H₃₅ClF₂N₃O₉P 
• 880596-94-1 C₃₅H₃₆ClF₂N₄O₈P 
• 880595-63-1 C₃₆H₃₇ClF₂N₃O₉P 
• 880595-07-3 C₃₁H₃₃Cl₂F₂N₂O₅P 
• 156017-45-7 (S)-2-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-3-{4-[(diethoxyphosphoryl)difluoromethyl]phenyl}propanoic acid 

Relevant articles and documents

Enantioselective synthesis of N-Boc and N-Fmoc protected diethyl 4-phosphono(difluoromethyl)-L-phenylalanine; agents suitable for the solid-phase synthesis of peptides containing nonhydrolyzable analogues of O-phosphotyrosine

Enantioselective convergent syntheses of N-Boc and N-Fmoc protected diethyl 4-phosphono(difluoromethyl)-L-phenylalanine are reported.

PENTAFLUOROPHOSPHATE DERIVATIVE, ITS USES AND AN APPROPRIATE MANUFACTURING METHOD

The invention relates to a pentafluorophosphate derivative according to general formula (I): or a pharmaceutically acceptable salt or solvate thereof. Thereby, R1 and R2 denote independently from each other H or F; R3 denotes H, an optionally substituted C1-C10 alkyl, an optionally substituted C3-C10 cycloalkyl, or an optionally substituted C6-C20 aryl, wherein a hydrocarbon chain of the alkyl, the cycloalkyl or the aryl can be interrupted by one or more oxygen, sulfur and/or nitrogen atoms; and M denotes any cation; with the proviso that at least one of R1 and R2 denotes F, if R3 denotes H. The invention further relates to uses of such a pentafluorophosphate derivative and to an appropriate manufacturing method.

PRODRUGS OF DRUG-PHOSPHATE CONJUGATES AND ANALOGS THEREOF

Phosphate-substituted therapeutic compounds and analogs thereof that may serve as prodrugs are described. The prodrugs may include phosphorus-containing compounds, drug-phosphate conjugates, and analogs of drug-phosphate conjugates. Also described are ana