157020-35-4

Basic information

• Product Name: cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester
• Synonyms: cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester
• CAS NO: 157020-35-4
• Molecular Weight: 391.532
• Mol File: 157020-35-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester(157020-35-4)
• EPA Substance Registry System: cis-4(R)-(6-Carboxyhex-1-enyl)-2(R)-phenylthiazolidine-3-carboxylic acid tert-butyl ester(157020-35-4)

Safety Data

• Hazardous Substances Data: 157020-35-4(Hazardous Substances Data)

Upstream product

• 196930-46-8 (4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid 
• 1027267-16-8 (2R,4R)-2-Phenyl-thiazolidine-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester 
• 161458-78-2 (2R,4R)-4-(hydroxymethyl)-2-phenylthiazolidine-3-carboxylic acid tert-butyl ester 
• 158446-52-7 (2R,4R)-3-(tert-butoxycarbonyl)-2-phenylthiazolidine-4-carboxylic acid 
• 100-52-7 benzaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4224-70-8 6-bromohexanoic acid 
• 50889-29-7 (5-carboxypentyl)triphenylphosphonium bromide 
• 157020-34-3 (2R,4R)-4-formyl-2-phenylthiazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 58-85-5 biotin 
• 161458-90-8 (2R,4R)-4-((Z)-6-Methoxycarbonyl-hex-1-enyl)-2-phenyl-thiazolidine-3-carboxylic acid tert-butyl ester 
• 76335-62-1 5-[(3aS)-1( oder !3)-benzyl-2-oxo-(3ar,6ac)-hexahydro-thieno[3,4-d]imidazol-4t-yl]-valeric acid 
• 161458-82-8 C₂₅H₃₀N₄O₃S 
• 1026060-14-9 C₂₅H₃₀ClNO₃S 
• 1026489-89-3 (Z)-(R)-9-Benzylsulfanyl-8-tert-butoxycarbonylamino-non-6-enoic acid methyl ester 
• 161458-81-7 (Z)-(R)-8-Benzylamino-9-benzylsulfanyl-non-6-enoic acid methyl ester 
• 161458-80-6 (Z)-(R)-8-Amino-9-benzylsulfanyl-non-6-enoic acid methyl ester 
• 161458-85-1 (Z)-(R)-9-{[1-Phenyl-meth-(E)-ylidene]-amino}-3,4,5,6,9,10-hexahydro-thiecin-2-one 
• 157020-40-1 -(3,6,7,8,9,10-Hexahydro-10-oxo-2H-thiecin-3-yl)-(phenylmethyl)carbamoyl azide 
• 157020-39-8 (Z)-(R)-9-Benzylamino-3,4,5,6,9,10-hexahydro-thiecin-2-one 
• 83541-80-4 <3aS-(3aα,4β,6aα)>-Hexahydro-2-oxo-3-(phenylmethyl)-1H-thieno<3,4-d>imidazole-4-pentanoic acid methyl ester 

Relevant articles and documents

A novel enantioselective synthesis of (+)-biotin

A conceptually attractive enantioselective 12-step synthesis of (+)-biotin from L-cysteine is reported based upon an intramolecular 1,3-dipolar cycloaddition sequence involving as key-steps (i) the macrothiolactonisation of acid 3 to Z-olefin (4), (ii) the thermolysis of the ene carbamoyl azide 5 in water with direct formation of a mixture of the benzylated derivative of (+)-biotin 6a and 6b.