15779-52-9Relevant academic research and scientific papers
A new route to amino-2-propanol structures with adrenergic β-blocker activity using low valent titanium
Bermudez,Del Campo,Sinisterra,Llama
, p. 4137 - 4140 (2007/10/03)
Amino-2-propanol structures can be obtained by addition to dibenzyl acetals of in situ generated dihalocarbenes using LTV (Low Valent Titanium). This methodology can be used to obtain adrenergic β-blockers with amino-2-propanol structure. Tetrahalomethane are the best dihalocarbene precursors. The yields obtained using halofluromethanes can be increased by addition of carbontetrachloride. A process that can imply halogen transfer may be proposed.
"PALLADIUM COMPLEXES-KF / ALUMINA" CATALYSED EXCHANGE OF ALLYLIC GROUPS OF ESTERS WITH PHENOL
Muzart, J.,Genet, J.-P.,Denis, A.
, p. C23 - C28 (2007/10/02)
In the presence of KF/alumina and catalytic amounts of palladium complexes, phenol reacts with allylic esters under mild conditions to give the corresponding allyl phenyl ethers.
MODIFICATION OF THE NICKL REACTION. A GENERAL SYNTHETIC APPROACH TO 2-VINYL-2,3-DIHYDROBENZOFURANS
Bigi, Franca,Casiraghi, Giovanni,Casnati, Giuseppe,Sartori, Giovanni
, p. 169 - 174 (2007/10/02)
The annelation reaction of metal phenolates 1 with 1,4-dibromo-2-butenes 2 to give 2-vinyl-2,3-dihydrobenzofuran derivatives 3 (Nickl reaction) was critically examined and markedly improved.Use of lithium phenolates, instead of sodium phenolates, as substrates and toluene, instead of methanol, as reaction medium, caused the yield of annelated compounds to rise dramatically.The relevance of this modified route to the synthesis of Euparinoid 2,3-dihydrobenzofurans and their synthetic analogues was emphasized.
