Synthesis of the core structure of apicularen a by transannular cyclization.

Article abstract of DOI:10.1021/ol017261d

[reaction: see text] An approach to the macrocyclic core of apicularen A is described. Thus, cross-coupling of the aryl triflate 7 with the vinylstannane 19 provided the styrene 20. Deprotection led to the dihydroxy acid 22. Through a size-selective macro