158267-48-2Relevant academic research and scientific papers
Methods of treating disease through the administration of a manzamine analog or derivative
-
, (2008/06/13)
A method of treating cancer, inflammatory disease or an infectious disease or condition in a subject in need of such treatment is disclosed. The method comprises administering to a subject an effective amount of a manzamine, or a rationally modified manzamine derivative or analog or an optical isomer or racemate or tautomer thereof or a pharmaceutically acceptable salt or prodrug thereof generated through optimized fermentation of a Micromonospora sp., extraction from sponges and then modified through semisynthesis.
Total synthesis of (+)-papuamine: An antifungal pentacyclic alkaloid from a marine sponge, Haliclona sp.
Barrett,Boys,Boehm
, p. 685 - 699 (2007/10/03)
The total synthesis of (+)-papuamine, the antipode of the C2-symmetric, optically active, pentacyclic diamine natural product, starting from a chiral diol is described. The diol is available via an asymmetric Diels-Alder reaction between 1,3-bu
Total Synthesis of (+)-Papuamine: Determination of the Absolute Stereochemistry of the Natural Product
Barrett, Anthony G. M.,Boys, Mark L.,Boehm, Terri L.
, p. 1881 - 1882 (2007/10/02)
The total synthesis of (+)-papuamine has been completed using an intramolecular Pd0 catalysed (Stille) coupling reaction to close the central diazadiene macrocycle unit.
