158267-58-4Relevant academic research and scientific papers
Total synthesis of (+)-papuamine: An antifungal pentacyclic alkaloid from a marine sponge, Haliclona sp.
Barrett,Boys,Boehm
, p. 685 - 699 (2007/10/03)
The total synthesis of (+)-papuamine, the antipode of the C2-symmetric, optically active, pentacyclic diamine natural product, starting from a chiral diol is described. The diol is available via an asymmetric Diels-Alder reaction between 1,3-bu
Total Synthesis of (+)-Papuamine: Determination of the Absolute Stereochemistry of the Natural Product
Barrett, Anthony G. M.,Boys, Mark L.,Boehm, Terri L.
, p. 1881 - 1882 (2007/10/02)
The total synthesis of (+)-papuamine has been completed using an intramolecular Pd0 catalysed (Stille) coupling reaction to close the central diazadiene macrocycle unit.
