15832-69-6

Basic information

• Product Name: 1-(4-BROMOPHENYL)-1-PHENYLETHAN-1-OL
• Synonyms: 1-(4-BROMOPHENYL)-1-PHENYLETHAN-1-OL;1-(4-BROMOPHENYL)-1-PHENYLETHAN-1-OL(WXG01571);4-Bromo-α-methyl-α-phenylbenzenemethanol
• CAS NO: 15832-69-6
• Molecular Formula: C₁₄H₁₃BrO
• Molecular Weight: 277.15642
• Mol File: 15832-69-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Solubility: DCM, Ether
• CAS DataBase Reference: 1-(4-BROMOPHENYL)-1-PHENYLETHAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BROMOPHENYL)-1-PHENYLETHAN-1-OL(15832-69-6)
• EPA Substance Registry System: 1-(4-BROMOPHENYL)-1-PHENYLETHAN-1-OL(15832-69-6)

Safety Data

• Hazardous Substances Data: 15832-69-6(Hazardous Substances Data)

Usage

Uses

4-Bromo-α-methyl-α-phenylbenzenemethanol is an intermediate in the synthesis of Embramine Hydrochloride (E521000), an antihistaminic.

Upstream product

• 99-90-1 para-bromoacetophenone 
• 591-51-5 phenyllithium 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 75-16-1 methylmagnesium bromide 
• 108-86-1 bromobenzene 
• 106-37-6 1.4-dibromobenzene 
• 98-86-2 acetophenone 
• 100-58-3 phenylmagnesium bromide 
• 16635-23-7 phenyltriisopropoxytitanium(IV) 
• 18006-13-8 methyltriisopropoxytitanium(IV) 
• 4333-76-0 1-(4-bromophenyl)-1-phenylethene 

Downstream Products

• 4333-76-0 1-(4-bromophenyl)-1-phenylethene 
• 81329-28-4 1-(4-cyanophenyl)-1-phenylethylene 
• 1196395-41-1 1-phenyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanol 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 

Relevant articles and documents

A one-pot two-step synthesis of tertiary alcohols combining the biocatalytic laccase/TEMPO oxidation system with organolithium reagents in aerobic aqueous media at room temperature

The one-pot/two-step combination of enzymes and polar organometallic chemistry in aqueous media is for the first time presented as a proof-of-concept study. The unprecedented combination of the catalytic oxidation of secondary alcohols by the system laccase/TEMPO with the ultrafast addition (3 s reaction time) of polar organometallic reagents (RLi/RMgX) to thein situformed ketones, run under air at room temperature, allows the straightforward and chemoselective synthesis of tertiary alcohols with broad substrate scope and excellent conversions (up to 96%).

Compound used as Bruton tyrosine kinase inhibitor, and preparation method and application of compound

The invention provides a compound with a structure shown as the formula (I), or an isomer, pharmaceutically acceptable solvate and salt thereof, which is used as the Bruton tyrosine kinase inhibitor. The Bruton tyrosine kinase inhibitor has higher inhibit

BTK INHIBITORS

Provided are Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.