32937-55-6Relevant articles and documents
An Improved Process for the Enantioselective Synthesis of HCV NS5A Inhibitor Elbasvir (MK-8742) Chiral Amine Intermediate
Chapala, Vijaya Lakshmi,Katari, Naresh Kumar,Kerru, Nagaraju,Malavattu, Giri Prasad,Marisetti, Vishnu Murthy,Reddy, Pedavenkatagari Narayana
, p. 932 - 938 (2021/06/26)
Abstract: Large-scale enantioselective synthesis of the chiral amine unit of HCV NS5A inhibitor Elbasvir has been accomplished in six steps, with 55% overall yield. The process includes a highly enantioselective reduction of the NH imine using R-(+)-diphe
Facile synthesis of 1-naphthols through a copper-catalyzed arylation of methyl ketones with o-bromoacetophenones
Lou, Zhen-Bang,Pang, Xin-Long,Chen, Chao,Wen, Li-Rong,Li, Ming
supporting information, p. 1231 - 1235 (2015/12/30)
The coupling reactions of simple methyl ketones with o-bromoacetophenones and subsquential cyclization reactions were realized to produce a range of 1-naphthols. These cascade reactions were initiated by a rare Cu-catalyzed arylation reaction of methyl ketones with aromatic bromides.
Synthesis and characterization of chiral benzylic ether-bridged periodic mesoporous organosilicas
Morell, Juergen,Chatterjee, Sangam,Klar, Peter J.,Mauder, Daniel,Shenderovich, Ilja,Hoffmann, Frank,Froeba, Michael
scheme or table, p. 5935 - 5940 (2009/05/31)
The first synthesis of a chiral periodic mesoporous organosilica (PMO) carrying benzylic ether bridging groups is reported. By hydrolysis and condensation of the new designed chiral organosilica precursor 1,4-bis(triethoxysilyl)-2-(1 -methoxyethyl)benzene