1588-44-9Relevant articles and documents
Cobalt-catalyzed coupling reaction of alkyl halides with allylic grignard reagents
Tsuji, Takashi,Yorimitsu, Hideki,Oshima, Koichiro
, p. 4137 - 4139 (2002)
Facile construction of quaternary carbon centers: The cobalt-catalyzed coupling reaction of not only primary and secondary but also tertiary alkyl halides with allylic Grignard reagents proceeds smoothly (see scheme; dppp = 1,3-bis(diphenylphosphanyl)prop
Synthesis of alkyl sulfones from alkenes and tosylmethylphosphonium iodide through photo-promoted cc bond formation
Miura, Tomoya,Miyakawa, Sho,Moriyama, Daisuke,Murakami, Masahiro
, p. 1382 - 1385 (2020)
A new synthetic method for alkyl sulfones through CC bond formation between alkenes and tosylmethylphosphonium iodide is reported. A tosylmethyl radical is generated from the phosphonium iodide under irradiation of visible light with the aid of fac-Ir(ppy)3. It undergoes regioselective 1,2-addition across the carboncarbon double bond to afford an elongated alkyl radical, which abstracts a hydrogen atom from C6F5SH, producing an alkyl sulfone with one-carbon extension.
Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis
Nouaille, Augustin,Pannecoucke, Xavier,Poisson, Thomas,Couve-Bonnaire, Samuel
, p. 2140 - 2147 (2021/03/06)
Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).
Palladium and Nickel Catalyzed Suzuki Cross-Coupling with Alkyl Fluorides
Balaraman, Kaluvu,Wolf, Christian
supporting information, p. 8994 - 8999 (2021/11/20)
Suzuki cross-coupling of benzylic and unactivated aliphatic fluorides with aryl- and alkenylboronic acids has been achieved via mechanistically distinct Pd and Ni catalyzed pathways that outperform competing protodeboronation, β-hydride elimination, and h
