27976-27-8Relevant academic research and scientific papers
Synthetic method of 3-(6-phenylhexyl) phenylboronic acid and derivatives thereof
-
Paragraph 0021-0023; 0026-0030; 0033-0037; 0040-0044; ..., (2021/07/17)
The invention discloses a synthetic method of 3-(6-phenylhexyl) phenylboronic acid and derivatives thereof, and relates to the technical field of chemical synthesis. The synthesis method of 3-(6-phenylhexyl) phenylboronic acid and derivatives thereof comprises the following synthesis steps: S1, synthesizing an intermediate H from a reactant B and a reactant D by utilizing a low-temperature synthesis step; S2, synthesizing an intermediate I from the reactant F and the intermediate H by utilizing a low-temperature synthesis step; and S3, synthesizing a finished product from a reactant G and the intermediate I by utilizing a low-temperature synthesis step. The invention provides the novel synthesis method of 3-(6-phenylhexyl) phenylboronic acid and derivatives thereof, the reaction steps are shortened to three steps, the materials are simple, the raw materials can be recycled, the reaction yield is improved, and the method has a series of advantages of short reaction time, simplicity in operation, capability of amplifying continuous production, reduction of the reaction cost and the like.
Mild Base Promoted Nucleophilic Substitution of Unactivated sp3-Carbon Electrophiles with Alkenylboronic Acids
Liu, Shiwen,Zeng, Xiaojun,Hammond, Gerald B.,Xu, Bo
, p. 3667 - 3671 (2018/09/12)
Diverse alkenylboronic acids react smoothly with various sp3-carbon electrophiles such as unactivated alkyl triflates in the presence of mild bases such as K3PO4. The reaction protocol is very mild and thereby enables high functional group tolerance. This transition metal-free condition is orthogonal towards the classic transition metal catalyzed Suzuki coupling. (Figure presented.).
Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides
Babkov, Denis A.,Khandazhinskaya, Anastasia L.,Chizhov, Alexander O.,Andrei, Graciela,Snoeck, Robert,Seley-Radtke, Katherine L.,Novikov, Mikhail S.
, p. 7035 - 7044 (2015/11/11)
The need for novel therapeutic options to fight herpesvirus infections still persists. Herein we report the design, synthesis and antiviral evaluation of a new family of non-nucleoside antivirals, derived from 1-[ω-(4-bromophenoxy)alkyl]uracil derivatives - previously reported inhibitors of human cytomegalovirus (HCMV). Introduction of the N-(4-phenoxyphenyl)acetamide side chain at N3 increased their potency and widened activity spectrum. The most active compounds in the series exhibit submicromolar activity against different viral strains of HCMV and varicella zoster virus (VZV) replication in HEL cell cultures. Inactivity against other DNA and RNA viruses, including herpes simplex virus 1/2, points to a novel mechanism of antiviral action.
Aluminum porphyrin complexes via delicate ligand design: Emerging efficient catalysts for high molecular weight poly(propylene carbonate)
Sheng, Xingfeng,Wang, Yong,Qin, Yusheng,Wang, Xianhong,Wang, Fosong
, p. 54043 - 54050 (2015/02/02)
Due to the deep concern over residual, toxic cobalt or chromium from catalysts in biodegradable poly(propylene carbonate) (PPC), bifunctional aluminum porphyrin complexes with quaternary ammonium salts anchored on the ligand framework were prepared, and a delicate design of the porphyrin ligand was obtained. An optimized catalyst was complex 6b, which had two para-bromine benzenes and two quaternary ammonium cations linked to benzene via a six-methylene spacer in the meso-position of the porphyrin framework and NO3- as axial ligand and quaternary ammonium anion, showed TOF of 560 h-1 at 80 °C and 3 MPa to yield PPC with 94% carbonate linkage and number average molecular weight of 96 kg mol-1. The PPC selectivity reached 93%, which was the highest record in this copolymerization for aluminum porphyrin complexes. The soil tolerant bifunctional aluminum porphyrin complexes are becoming increasingly competitive catalysts, since they can be left with the plastics without any extra separation. This journal is
RECYCLING OF ORGANOTIN COMPOUNDS
-
Page/Page column 44, (2013/12/03)
A method for the synthesis of a first organic molecule, said method comprising the steps of: a) Reacting a first reactant with an organotin reactant having at least one optionally substituted organic group having from 5 to 20 carbon atoms selected from alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkylthioalkyl, carboxylates and alkylaminoalkyl groups, thereby forming a mixture of a product and a tin-containing by-product, and b) Removing most of the tin-containing by-product from said mixture in such a way as to provide a purified product comprising less than 1000 ppm of remaining tin-containing by- product, wherein said step of removing most of said tin-containing by-product is either an extraction between a first liquid and a second liquid, said second liquid being more polar than said first liquid and at least partly immiscible therewith or is a reversed phase chromatography.
Effect of composition on the catalytic properties of mixed-ligand-coated gold nanoparticles
Ghosh, Anirban,Basak, Soubir,Wunsch, Benjamin H.,Kumar, Rajiv,Stellacci, Francesco
experimental part, p. 7900 - 7905 (2011/10/08)
Striped catalysts: The effect of composition and structure on the catalytic efficiency of gold nanoparticles protected by a monolayer composed of two types of ligands differing in length (see picture) is reported. By diluting catalytically active ligand molecules with simple catalytically inactive molecules the catalytic efficiency of the particles is enhanced.
Dangling arms: A tetrahedral supramolecular host with partially encapsulated guests
Tiedemann, Bryan E. F.,Raymond, Kenneth N.
, p. 83 - 86 (2007/10/03)
A protruding tail: A guest composed of a cationic sandwich complex, an alkyl chain, and a sulfonate anionic group is partially incorporated within a host [Ga4L6]12- cluster (see scheme). The cationic head group is quickly incorporated into the cavity of the host, while the sulfonate unit at the other end of the chain is not, as the alkyl sulfonate tail protrudes through an opening in a triangular face of the tetrahedral cluster. (Figure Presented).
Synthesis of Cp*CH2PPh2 and its use as a ligand for the nickel-catalysed cross-coupling reaction of alkyl halides with aryl Grignard reagents
Uemura, Minoru,Yorimitsu, Hideki,Oshima, Koichiro
, p. 4726 - 4728 (2007/10/03)
A new ligand, Cp*CH2PPh2 (Cp* = 1,2,3,4,5-pentamethyl-2,4-cyclopentadienyl), was prepared, and was used as a ligand for nickel-catalysed cross-coupling reaction of alkyl halides with aryl Grignard reagents, which nickel-phosphine complexes had never made possible. The Royal Society of Chemistry.
Pd-Catalyzed Cross-Coupling Reaction of Alkyl Tosylates and Bromides with Grignard Reagents in the Presence of 1,3-Butadiene
Terao, Jun,Naitoh, Yoshitaka,Kuniyasu, Hitoshi,Kambe, Nobuaki
, p. 890 - 891 (2007/10/03)
A new method for cross-coupling reaction of alkyl tosylates and bromides with Grignard reagents has been developed by the use of Pd(acac)2 or PdCl2 as the catalyst. Addition of 1,3-butadiene is essential to afford good yields of coupling products. This reaction proceeds efficiently at room temperature using primary and secondary alkyl and aryl Grignard reagents.
Azetidinone derivatives for the treatment of atherosclerosis
-
, (2008/06/13)
PCT No. PCT/EP95/04202 Sec. 371 Date Sep. 30, 1997 Sec. 102(e) Date Sep. 30, 1997 PCT Filed Oct. 25, 1995 PCT Pub. No. WO96/13484 PCT Pub. Date May 9, 1996Azetidinone derivatives of formula (I) in which R1 and R2, which may be the same or different, is each selected from hydrogen or C(1-8)alkyl; R3 is C(1-8)alkyl or C(3-8)cycloalkyl each of which may be optionally substituted; X is a linker group; Y is an aryl group; and n is 0, 1 or 2; and excluding benzyl (4-methylthio-2-oxo-azetidin-1-yl)acetate are inhibitors of the enzyme Lp PLA2 and are of use in therapy, in particular treating atherosclerosis.
