15937-64-1Relevant academic research and scientific papers
N,N'-Doacylated imidazolidines and hexahydropyrimidines
Luk'yanov, O. A.,Pokhvisneva, G. V.,Ternikova, T. V.
, p. 1376 - 1380 (2007/10/02)
A method for the preparation of N-monoacyl imidazolidines and hexahydropyrimidines (as hydrochlorides) by interaction of monoacylated derivatives of ethylenediamine and trimethylethylenediamine with chloromethyl methyl ether was developed.Also a method for the preparation of N,N'-diacylimidazolidines and hexahydropyrimidines either by acylation of their monoacyl derivatives or by reaction of the corresponding N,N'-diacyl alkylenediamine derivatives with dimethoxymethane, diacetoxymethane, 1,3,5-trioxane or chloromethyl methyl ether was designed. - Key words: N-mono- and N,N'-diacylated imidazolidines, N-mono- and N,N'-diacylated hexahydropyrimidines, N,N'-diacylated alkylenediamines, acylation, methylation, cyclization.
Acyl Derivatives of Cyclic Secondary Amines. Part 1. Dipole Stabilization of Anions: the Cumulative effect of Two Stabilizing Groups
Katritzky, Alan R.,Murugan, Ramiah,Luce, Hudson,Zerner, Michael,Ford, George P.
, p. 1695 - 1700 (2007/10/02)
Lithiation studies with diacylimidazolidines, diacylhexahydropyrimidines, and triacylhexahydro-1,3,5-triazines indicate that no substantial increase in carbanion stability occurs as a result of the introduction of the second stabilizing group.Relative energies are calculated for three conformers of lithiated diformylimidazolidine, six conformers of lithiated diformylhexahydropyrimidine, and eight conformers of lithiated triformylhexahydro-sym-triazine.For the six-membered rings, conformers with equatorial lithium are always more stable those those with axial lithium.Although equatorial syn-syn conformers (with double O-Li co-ordination) are more stable than equatorial syn-anti, the difference is significantly less than that found between the corresponding syn-anti and (least stable) anti-anti conformers.
