15991-59-0

Basic information

• Product Name: (+/-)-2-PROPYLPIPERIDINE HYDROCHLORIDE*
• Synonyms: Piperidine,2-propyl-, hydrochloride (8CI,9CI); (?à)-Coniine hydrochloride; 2-Propylpiperidinehydrochloride; DL-Coniine hydrochloride
• CAS NO: 15991-59-0
• Molecular Formula: C₈H₁₇N*ClH
• Molecular Weight: 163.68822
• Mol File: 15991-59-0.mol
• Article Data: 37

Chemical Properties

• Melting Point: ~210 °C(lit.)
• Boiling Point: 166.2°C at 760 mmHg
• Flash Point: 48.4°C
• Appearance: /
• Vapor Pressure: 1.8mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (+/-)-2-PROPYLPIPERIDINE HYDROCHLORIDE*(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-2-PROPYLPIPERIDINE HYDROCHLORIDE*(15991-59-0)
• EPA Substance Registry System: (+/-)-2-PROPYLPIPERIDINE HYDROCHLORIDE*(15991-59-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 15991-59-0(Hazardous Substances Data)

Usage

General Description

(+/-)-2-PROPYLPIPERIDINE HYDROCHLORIDE* is a chemical compound that is commonly used as a building block in the synthesis of pharmaceuticals and other biologically active compounds. It is an organic compound with the molecular formula C9H20ClN and has a molar mass of 183.71 g/mol. The hydrochloride salt form of this compound is commonly used in various chemical reactions due to its stability and solubility in water. It is also used as a precursor in the synthesis of other piperidine-based compounds, and its structure and properties make it suitable for a wide range of applications in chemical research and industry.

InChI:InChI=1/C8H17N.ClH/c1-2-5-8-6-3-4-7-9-8;/h8-9H,2-7H2,1H3;1H/t8-;/m0./s1

Upstream product

• 944128-18-1 (-)-(6S,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-propylpiperidin-2-one 
• 98195-27-8 1-benzyl-2-n-propylpiperidine 
• 344797-51-9 (1'R)-(-)-1-(2'-hydroxy-1'-phenyl-ethyl)-3,4-dihydro-(1H)-pyridin-2-one 
• 211919-57-2 (1'R)-(-)-1-(2'-hydroxy-1'-phenyl-ethyl)-(1H)-pyridin-2-one 
• 152555-02-7 (3R,8aR)-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 767321-53-9 (2S)-4-(1,3-dithiolan-2-yl)-1-(2,3,4,6-tetra-O-pivaloyl-β-D-galactopyranosyl)-2-propylpiperidine 
• 683771-95-1 (1'R,6S)-(-)-1-(2'-hydroxy-1'-phenyl-ethyl)-6-n-propyl-piperidine-2-thione 
• 686341-95-7 (2S)-N-(2',3',4'-tri-O-pivaloyl-α-D-arabinopyranosyl)-2-n-propyl-5,6-dehydropiperidin-4-one 
• 901759-83-9 (2S)-N-(2',3'4'-tri-O-pivaloyl-α-D-arabinopyranosyl)-2-n-propyl-4-(trifluoromethanesulfonyloxy)-4,5-dehydropiperidine 
• 259249-36-0 1-(4-methoxyphenyl)-2-propylpiperidine 
• 944128-13-6 (-)-(6S,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-propyl-5,6-dihydro-1H-pyridin-2-one 
• 944128-08-9 (-)-(1S,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-(1-propylbut-3-enyl)acrylamide 
• 505-18-0 2,3,4,5-tetrahydropyridine 
• 902121-33-9 (2S)-N-(2',3'4'-tri-O-pivaloyl-α-D-arabinopyranosyl)-2-n-propylpiperidine 

Relevant articles and documents

Stereoselective total synthesis of the piperidine alkaloids, (+)-coniine, (+)-pseudoconhydrine, and (+)-sedamine through a common intermediate

The stereoselective total synthesis of the piperidine alkaloids, (+)-coniine, (+)-pseudoconhydrine and (+)-sedamine has been achieved through a common intermediate generated from butane-1,4-diol. The synthetic sequence involves a Maruoka asymmetric allylation and ring-closing metathesis as the key steps.

Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Allenes

The rhodium-catalyzed asymmetric intramolecular hydroamination of sulfonyl amides with terminal allenes is reported. It provides selective access to 5- and 6-membered N-heterocycles, scaffolds found in a large range of different bioactive compounds. Moreover, gram scale reactions, as well as the application of suitable product transformations to natural products and key intermediates thereof are demonstrated.

A direct and general method for the reductive alkylation of tertiary lactams/amides: Application to the step economical synthesis of alkaloid (-)-morusimic acid D

Full details of the direct and general method for the reductive alkylation of tertiary lactams and amides to give tertiary sec-alkylamines are presented. This one-pot method consists of in situ activation of a lactam or an amide with Tf2O/DTBMP, addition of a Grignard reagent, and reduction of the resulting iminium intermediates. Alkyl, benzyl, and aryl Grignard reagents and several reductants or reducing conditions (LiAlH4, NaBH4, Hantzsch ester, Bu3SnH, Pd(OH)2/C, H2) could be used effectively. Reductive alkylations of substituted lactams demonstrated good to excellent 1,3-asymmetric induction to provide the corresponding di- or trisubstituted pyrrolidine/piperidine in 6:1 (LiAlH4), 11:1 (Et 3SiH), and 20:1 (catalytic hydrogenation) cis/trans diastereoselectivity, respectively. The versatility of this methodology was demonstrated by its application in the concise stereoselective synthesis of piperidine alkaloid (-)-morusimic acid.