1600565-75-0

Basic information

• Product Name: 4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile
• Synonyms: 4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile
• CAS NO: 1600565-75-0
• Molecular Weight: 485.372
• Mol File: 1600565-75-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile(1600565-75-0)
• EPA Substance Registry System: 4-chloro-6-((4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl)-3-phenylquinoline-2-carbonitrile(1600565-75-0)

Safety Data

• Hazardous Substances Data: 1600565-75-0(Hazardous Substances Data)

Upstream product

• 557-21-1 zinc(II) cyanide 
• 1600565-48-7 (4-chlorophenyl)(2,4-dichloro-3-phenylquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol 
• 103-80-0 phenylacetyl chloride 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 76-05-1 trifluoroacetic acid 
• 1600562-81-9 6-bromo-2,4-dichloro-3-phenylquinoline 
• 2613-89-0 phenylmalonic acid 
• 106-40-1 4-bromo-aniline 
• 909365-96-4 6-bromo-4-hydroxy-3-phenylquinolin-2(1H)-one 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 122-01-0 4-chloro-benzoyl chloride 
• 452349-62-1 methyl 5-bromo-2-(2-phenylacetamido)benzoate 

Relevant articles and documents

Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt

A high-throughput screen of the ligand binding domain of the nuclear receptor retinoic acid-related orphan receptor gamma t (RORγt) employing a thermal shift assay yielded a quinoline tertiary alcohol hit. Optimization of the 2-, 3- and 4-positions of the quinoline core using structure-activity relationships and structure-based drug design methods led to the discovery of a series of modulators with improved RORγt inhibitory potency and inverse agonism properties.