1601-00-9Relevant academic research and scientific papers
TRANSFORMATIONS OF CYCLOALKANES UNDER THE ACTION OF ACYL HALIDES IN THE PRESENCE OF AlBr3.
Akhrem, I.S.,Orlinkov, A.V.,Mysov, E.I.,Vol'pin, M.E.
, p. 3891 - 3894 (1981)
Cycloalkanes have been found to react with acyl halides in the presence of AlBr3 ( mole ratio RCOX:AlBr3=1:2 ) under very mild conditions affording products of hydrocarbon oxidative coupling or/and hydrocarbon acylation.
Electrochemical Coupling of Biomass-Derived Acids: New C8 Platforms for Renewable Polymers and Fuels
Wu, Linglin,Mascal, Mark,Farmer, Thomas J.,Arnaud, Sacha Pérocheau,Wong Chang, Maria-Angelica
, p. 166 - 170 (2017/01/17)
Electrolysis of biomass-derived carbonyl compounds is an alternative to condensation chemistry for supplying products with chain length >C6for biofuels and renewable materials production. Kolbe coupling of biomass-derived levulinic acid is used to obtain 2,7-octanedione, a new platform molecule only two low process-intensity steps removed from raw biomass. Hydrogenation to 2,7-octanediol provides a chiral secondary diol largely unknown to polymer chemistry, whereas intramolecular aldol condensation followed by hydrogenation yields branched cycloalkanes suitable for use as high-octane, cellulosic gasoline. Analogous electrolysis of an itaconic acid-derived methylsuccinic monoester yields a chiral 2,5-dimethyladipic acid diester, another underutilized monomer owing to lack of availability.
COMPOUNDS USEFUL AS MODULATORS OF TRPM8
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Paragraph 0601, (2016/03/29)
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formulae (Ia), (Ib) and (Ic), and the subgenus and species thereof; personal products containing those compounds; and the use of those compounds and the personal products, particularly the use of increasing or inducing chemesthetic sensations, such as cooling or cold sensations.
Efficient Cu-catalyzed asymmetric conjugate additions of alkylzincs to trisubstituted cyclic enones
Degrado, Sylvia J.,Mizutani, Hirotake,Hoveyda, Amir H.
, p. 13362 - 13363 (2007/10/03)
The first examples of efficient catalytic asymmetric conjugate addition (ACA) of alkylzincs to trisubstituted cyclic enones is disclosed. These Cu-catalyzed reactions proceed efficiently with five- and seven-membered ring substrates to afford the desired products in ≥95% ee. Intermediate enolates can be trapped with alkyl halides to generate a quaternary stereogenic center. The requisite chiral ligand is prepared from commercially available materials and can be used in situ without further purification in the presence of commercial grade (CuOTf)2·PhMe. Copyright
Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to acyclic aliphatic enones
Mizutani, Hirotake,Degrado, Sylvia J.,Hoveyda, Amir H.
, p. 779 - 781 (2007/10/03)
Cu-catalyzed enantioselective conjugate additions to acyclic aliphatic enones are reported. The resulting enolates may be functionalized intra- and intermolecularly, leading to the formation of an additional C-C bond. The utility of the present method is not limited to reactions involving Et2Zn; a variety of alkylzincs may be used. Moreover, many of the requisite substrates can be easily accessed through catalytic olefin cross metathesis. Copyright
