A novel synthesis of the antipsychotic agent ziprasidone

Article abstract of DOI:10.1080/00397919608003533

A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-nitrotoluene 3 is presented. The nitro group in 3 was used to activate the orthochlorine for displacement and the methyl group for enamine formation and introduction of the piperazinyl moiety.

Full text of DOI:10.1080/00397919608003533

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Novel Synthesis of
the Antipsychotic Agent
Ziprasidone
Frank J. Urban a , Ralph Breitenbach a & Dianne
Gonyaw a
a Pfizer Inc, Central Research Division, Process
Research and Development Eastern Point Rd.,
Groton, CT, 06340
Published online: 15 Aug 2006.
To cite this article: Frank J. Urban , Ralph Breitenbach & Dianne Gonyaw (1996): A
Novel Synthesis of the Antipsychotic Agent Ziprasidone, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
26:8, 1629-1638
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