162042-41-3

Basic information

• Product Name: tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate
• CAS NO: 162042-41-3
• Molecular Weight: 565.667
• Mol File: 162042-41-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate(162042-41-3)
• EPA Substance Registry System: tert-butyl 4-(3-methoxy-4-(4-(2-oxo-2H-benzo[d][1,3]oxazin-1(4H)-yl)piperidine-1-carbonyl)phenoxy)piperidine-1-carboxylate(162042-41-3)

Safety Data

• Hazardous Substances Data: 162042-41-3(Hazardous Substances Data)

Upstream product

• 162045-30-9 1-(N-t-butyloxy-carbonyl-4-piperidinyl)-4H-3,1-benzoxazin-2(1H)-one 
• 162045-37-6 4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-methoxybenzoic acid methyl ester 
• 162045-36-5 4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-hydroxybenzoic acid methyl ester 
• 162045-29-6 1-(tert-Butoxycarbonyl)-4-[(2-hydroxymethylphenyl)amino]piperidine 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 5344-90-1 2-Aminobenzyl alcohol 
• 162045-38-7 4-(N-t-Butoxycarbonyl-4-piperidinyloxy)-2-methoxy-benzoic acid 
• 162045-31-0 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride 

Downstream Products

• 208517-38-8 1-(1-{2-methoxy-4-[1-(2-methylpyridin-3-ylcarbonyl)piperidin-4-yloxy]benzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one 
• 162045-26-3 1-(1-4-(1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxyl-2-methoxybenzoyl)piperidin-4-yl)-1,4-dihydrobenz(d)(1,3)oxazin-2-one 
• 162042-44-6 1-(1-(4-((N-acetyl-4-piperidinyl)oxy)-2-methoxybenzoyl)piperidin-4-yl)-4H-3,1-benzoxazin-2(1H)-one 

Relevant articles and documents

Development of orally active oxytocin antagonists: Studies on 1-(1-{4- [1-(2-methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy].2methoxybenzoyl}- 4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and related pyridines

The previously reported oxytocin antagonist L-371,257 (2) has been modified at its acetylpiperidine terminus to incorporate various pyridine N- oxide groups. This modification has led to the identification of compounds with improved pharmacokinetics and excellent oral bioavailability. The pyridine N-oxide series is exemplified by L-372,662 (30), which possessed good potency in vitro (Ki = 4.1 nM, cloned human oxytocin receptor) and in vivo (intravenous AD50 = 0.71 mg/kg in the rat), excellent oral bioavailability (90% in the rat, 96% in the dog), good aqueous solubility (>8.5 mg/mL at pH 5.2) which should facilitate formulation for iv administration, and excellent selectivity against the human arginine vasopressin receptors. Incorporation of a 5-fluoro substituent on the central benzoyl ring of this class of oxytocin antagonists enhanced in vitro and in vivo potency but was detrimental to the pharmacokinetic profiles of these compounds. Although lipophilic substitution around the pyridine ring of compound 30 gave higher affinity in vitro, such substituents were a metabolic liability and caused shortfalls in vivo. Two approaches to prevent this metabolism, addition of a cyclic constraint and incorporation of trifluoromethyl groups, were examined. The former approach was ineffective because of metabolic hydroxylation on the constrained ring system, whereas the latter showed improvement in plasma pharmacokinetics in some cases.