162174-72-3Relevant articles and documents
Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases
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, (2010/02/05)
Certain 2H-pyran-2-ones are useful for treating benign prostatic hypertrophy or hyperplasia, prostatic cancer, alopecia, hirsutism, acne vulgaris and seborrhea.
Structure-based design of novel HIV protease inhibitors: Sulfonamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent non-peptidic inhibitors
Thaisrivongs, Suvit,Janakiraman, Musiri N.,Chong, Kong-Teck,Tomich, Paul K.,Dolak, Lester A.,Turner, Steve R.,Strohbach, Joseph W.,Lynn, Janet C.,Horng, Miao-Miao,Hinshaw, Roger R.,Watenpaugh, Keith D.
, p. 2400 - 2410 (2007/10/03)
The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents. Our broad screening program to discover non-peptidic HIV protease inhibitors previously identif