16440-97-4

Basic information

• Product Name: 5,6-Dimethyl-2,3-dihydro-1H-indene-1-one
• Synonyms: 5,6-Dimethyl-1-indanone;5,6-Dimethyl-2,3-dihydro-1H-indene-1-one;5,6-DiMethyl-2,3-dihydro-1H-inden-1-one;5,6-DiMethylindan-1-one;1H-Inden-1-one, 2,3-dihydro-5,6-diMethyl-
• CAS NO: 16440-97-4
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.2124
• Mol File: 16440-97-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 298.4°Cat760mmHg
• Flash Point: 127.4°C
• Appearance: /
• Density: 1.085g/cm³
• Vapor Pressure: 0.00127mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5,6-Dimethyl-2,3-dihydro-1H-indene-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Dimethyl-2,3-dihydro-1H-indene-1-one(16440-97-4)
• EPA Substance Registry System: 5,6-Dimethyl-2,3-dihydro-1H-indene-1-one(16440-97-4)

Safety Data

• Hazardous Substances Data: 16440-97-4(Hazardous Substances Data)

Usage

General Description

5,6-Dimethyl-2,3-dihydro-1H-indene-1-one is a chemical compound with the molecular formula C11H14O. It is a yellowish liquid with a sweet, floral odor and is used primarily as a fragrance ingredient in perfumes and other personal care products. It is also used in the flavor industry as a flavoring agent. The compound is synthesized through a series of chemical reactions involving various starting materials and reagents. It is important to handle this chemical with care as it may cause skin and eye irritation and is harmful if swallowed or inhaled. Additionally, it may have adverse effects on aquatic life if released into the environment.

InChI:InChI=1/C11H12O/c1-7-5-9-3-4-11(12)10(9)6-8(7)2/h5-6H,3-4H2,1-2H3

Upstream product

• 104174-69-8 3,4-dimethylbicyclo[4.3.0]non-3-en-9-one 
• 26801-37-6 3-(3,4-dimethylphenyl)propionyl chloride 
• 22422-23-7 3-chloro-1-(3,4-dimethyl-phenyl)-propan-1-one 
• 619-04-5 3,4-dimethylbenzoic acid 
• 95-47-6 o-xylene 
• 625-36-5 2-chloropropionyl chloride 
• 25173-76-6 3-(3,4-dimethylphenyl)propionic acid 
• 5973-71-7 3,4-dimethylbenzaldehyde 
• 38404-42-1 methyl 3,4-dimethylbenzoate 
• 147219-20-3 3-(3,4-Dimethylphenyl)-propensaeure 
• 6966-10-5 3,4-dimethylbenzyl alcohol 
• 27912-85-2 3-(benzyloxy)propanoic acid 
• 860722-62-9 5,6-dimethyl-3-oxo-indan-1-carboxylic acid 

Relevant articles and documents

The identification of indacaterol as an ultralong-acting inhaled β2-adrenoceptor agonist

Following a lipophilicity-based hypothesis, an 8-hydroxyquinolinone 2-aminoindan derived series of β2-adrenoceptor agonists have been prepared and evaluated for their potential as inhaled ultralong-acting bronchodilators. Determination of their activities at the human β2-adrenoceptor receptor showed symmetrical substitution of the 2-aminoindan moiety at the 5- and 6-positions delivered the targeted intermediate potency and intrinsic-efficacy profiles relative to a series of clinical reference β2-adrenoceptor agonists. Further assessment with an in vitro superfused electrically stimulated guinea-pig tracheal-strip assay established the onset and duration of action time courses, which could be rationalized by considering the lipophilicity, potency, and intrinsic efficacy of the compounds. From these studies the 5,6-diethylindan analogue indacaterol 1c was shown to possess a unique profile of combining a rapid onset of action with a long duration of action. Further in vivo profiling of 1c supported the long duration of action and a wide therapeutic index following administration to the lung, which led to the compound being selected as a development candidate.

TRANSITION METAL COMPOUND AND METHOD FOR PRODUCING OLEFIN POLYMER

PROBLEM TO BE SOLVED: To provide a transition metal compound catalyst that makes it possible to synthesize an olefin polymer that is soft and has improved catalytic activity and reduced stereoregularity, and a method for producing an olefin polymer. SOLUTION: The present invention provides a compound represented by formula (IV) (X is a σ-binding or π-binding ligand; Y is a Lewis base; Y may be crosslinked to other Y and X; q is an integer of 1-5 and [(valence of M)-2]; r is an integer of 0-3; R1 and R2 independently represent H or halogen, alkyl or the like; R3-R10 are alkyl groups. M is metal elements of groups 3-10 or lanthanoid series in the periodic table; A1-A4 independently represent a crosslinking group composed of group 14 (C, Si, Ge, Sn)). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

METALLOCENE COMPLEX AND METHOD FOR PRODUCING OLEFIN POLYMER

PROBLEM TO BE SOLVED: To provide a metallocene complex which, in homopolymerization of propylene, can produce homopolypropylene having a high melting point, and a method for producing an olefin polymer using the same. SOLUTION: Provided is a metallocene complex crosslinked by Si, such as dichlorosilacyclobutylenebis[2-(5-methyl-2-furyl)-4-phenyl-1,5,6,7-tetrahydro-s-indacen-1-yl]zirconium and dichlorosilacyclopentylenebis[2-(5-methyl-2-furyl)-4-phenyl-1,5,6,7-tetrahydro-s-indacen-1-yl]zirconium. Also provided is a catalyst for polymerizing an olefin such as propylene, comprising the complex, a compound which forms an ion pair by reacting with the complex or an ion-exchanging phyllosilicate, and an organoaluminum compound. COPYRIGHT: (C)2016,JPOandINPIT