25173-76-6

Usage

Uses

Used in Pharmaceutical Industry:
3-(3,4-DIMETHYLPHENYL)PROPIONIC ACID is used as a reagent for the preparation of pyrazolotetrahydropyridines, which are known as orexin receptor antagonists. These antagonists play a crucial role in the development of medications targeting various conditions, such as insomnia, addiction, and other disorders related to the central nervous system. The compound's unique structure allows it to interact with specific receptors, modulating their activity and providing therapeutic benefits.

InChI:InChI=1/C11H14O2/c1-8-3-4-10(7-9(8)2)5-6-11(12)13/h3-4,7H,5-6H2,1-2H3,(H,12,13)

Upstream product

• 147219-20-3 3-(3,4-Dimethylphenyl)-propensaeure 
• 5973-71-7 3,4-dimethylbenzaldehyde 
• 6966-10-5 3,4-dimethylbenzyl alcohol 
• 102-46-5 4-(chloromethyl)-1,2-dimethylbenzene 
• 105-53-3 diethyl malonate 
• 5779-93-1 2,3-dimethylbenzaldehyde 
• 79-10-7 acrylic acid 
• 7440-32-6 titanium 
• 60521-25-7 3,4-dimethylcinnamic acid 
• 619-04-5 3,4-dimethylbenzoic acid 
• 38404-42-1 methyl 3,4-dimethylbenzoate 

Downstream Products

• 26801-37-6 3-(3,4-dimethylphenyl)propionyl chloride 
• 16440-97-4 5,6-Dimethylindan-1-one 
• 16440-98-5 6,7-dimethyl-2,3-dihydro-1H-inden-1-one 
• 112631-49-9 3-(2-bromo-4,5-dimethylphenyl)propionic acid 
• 142332-70-5 3-(3,4-dimethylphenyl)propylamine 
• 1075-22-5 5,6-dimethylindane 

Relevant academic research and scientific papers

Aldehyde as a Traceless Directing Group for Regioselective C-H Alkylation Catalyzed by Rhodium(III) in Air

The aromatic aldehyde as a traceless directing group for the regionselective C-H alkylation catalyzed by rhodium(III) under aerobic atmospheric conditions has been developed. The process involves an aldehyde assisted direct addition of C-H bond to unsaturated electrophiles of acrylates or acrylic acids, and the subsequent decarbonylation. A trace amount of water is found to favor the reaction.

1,4,5,6, 7,8-HEXAHYDRO-I^1S-TRIAZA-AZULENE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The invention relates to 1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulene derivatives of formula (II), wherein the chirality is as depicted below, (II) and their use as orexin receptor antagonists.

5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I),wherein X represents CH2 or O; R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl; R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen; R4 represents (C1-4)alkyl; R5 represents hydrogen or (C1-4)alkyl; and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.

LIGANDS AND CATALYSTS FOR PRODUCING ELASTOMERIC PROPYLENE POLYMERS

A ligand useful to form a metallocene olefin polymerization catalyst comprises:wherein at least R3 and R4 are substituents having at least a bulk of a t-butyl group and, optionally, wherein R1 or R2 may be a bulky substituent group.

N-Arylalkylphenylacetamide derivatives

N-arylalkylphenylacetamide compounds of formula (I), and pharmaceutically acceptable salts thereof, possess potent analgesic and anti-inflammatory activities. STR1

Aromatic Spiranes XX [1]: Syntheses of Dimethylsubstituted 2-Carboxymethyl-indan-1-ones and Benzylchlorides as Synthones for Syntheses of di- to tetramethylsubstituted Spirobiindandiones

The isomeric dimethyl methylbenzoates 5, obtained from the bromides via Grignard reactions with dimethylcarbonate, were reduced with LiAlH4 to the hydroxymethyl derivatives 6. The latter were then transformed both to the benzylchlorides 7 (with SOCl2) and to the aldehydes 8 (with pyridinium chlorochromate). Knoevenagel-Doebner reaction of 8 afforded the acrylic acids 9 which (after hydrogenation to 11) were cyclized to the desired indanones 12 with polyphosphoric acid. On the other hand, 12c and 12e were prepared from dimethyl 3-chloropropiophenone (14) by warming with sulfuric acid. After NaH-catalyzed reaction with dimethylcarbonate, the indanones 12 gave the ketoesters 15 which then could be hydrogenated to the indanes 16. All reactions proceeded with satisfactory to excellent yields (60-90%).

N-arylalkylphenylacetamide derivatives

N-arylalkylphenylacetamide compounds of formula (I), and pharmaceutically acceptable salts thereof, possess potent analgesic and anti-inflammatory activities.

Phenylacetamide derivatives and pharmaceutical compositions thereof

The present invention provides novel phenylacetamide derivatives having the following formula STR1 wherein: X is a hydrogen, halogen, hydroxy, nitro, amino, R1, NR1 R2, NHR1 or OR1 wherein R1/su

Novel phenylacetamide derivatives and processes for the preparation thereof

The present invention provides novel phenylacetamide derivatives having the following formula wherein:, X is a hydrogen, halogen, hydroxy, nitro, amino, R1, NR1R2, NHR1 or OR1 wherein R1 and R2 are an optionally substituted C1 8 alky