16723-77-6

Basic information

• Product Name: 1,5-diphenyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazole
• Synonyms: 1,5-diphenyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazole
• CAS NO: 16723-77-6
• Molecular Formula: C₁₉H₁₆N₂S
• Molecular Weight: 304.40874
• Mol File: 16723-77-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,5-diphenyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-diphenyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazole(16723-77-6)
• EPA Substance Registry System: 1,5-diphenyl-3-(2-thienyl)-4,5-dihydro-1H-pyrazole(16723-77-6)

Safety Data

• Hazardous Substances Data: 16723-77-6(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 98-03-3 thiophene-2-carbaldehyde 
• 2910-81-8 3-(2'-thienyl)acrylophenone 
• 59-88-1 phenylhydrazine hydrochloride 
• 62985-06-2 3-phenyl-1-(thien-2-yl)prop-2-yn-1-ol 
• 100-63-0 phenylhydrazine 
• 100-52-7 benzaldehyde 
• 3988-77-0 3-phenyl-1-thiophen-2-yl-propenone 
• 88-15-3 2-Acetylthiophene 

Downstream Products

• 21178-99-4 1,5-diphenyl-3-(thiophen-2-yl)-1H-pyrazole 

Relevant articles and documents

TBHP/Cu(OAc)2 mediated oxidation of pyrazolines: A convenient method for the preparation of pyrazoles

An efficient and simple oxidative protocol has been developed for the preparation of pyrazoles from pyrazolines mediated by TBHP/Cu(OAc)2 at room temperature. The present protocol has been successfully applied for the preparation of various pyrazole compounds from heterocyclic pyrazolines.

A novel methodology for synthesis of dihydropyrazole derivatives as potential anticancer agents

A novel, simple, and efficient method for the synthesis of 4,5-dihydropyrazole derivatives has been developed. The reaction proceeded through the base-induced isomerization of easily accessible propargyl alcohols followed by cyclization of α,β-unsaturated hydrazones. Furthermore, selected compounds 3ab and 3ac exhibited good activities against Bel-7404 (human hepatoma cancer), HepG2 (human liver cancer), NCI-H460 (human lung cancer) and SKOV3 (human ovarian cancer) cell lines with IC50 in the range of 22-46 μmol L-1.

Synthesis of 3,5-disubstituted pyrazoles and their derivatives

2-Acetylthiophene condenses with different aromatic aldehyde in ethanol in the presence of aqueous NaOH to give 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-one (Ia-e) which reacts with hydrazine hydrate in ethanol to give pyrazoline (IIa-e) and also treated with DMSO in presence of catalytic amount of iodine to give pyrazole (II′a-e) Similarly, 1-phenyl pyrazoline (IIIa-e) treated with DMSO/I2 to give 1-phenyl pyrazole(III′a- e), 1-(2,4-dinitro phenyl) pyrazoline (IVa-e) treated with DMSO/I2 to give 1-(2,4-dinitro phenyl) pyrazole(IV′a-e), 1-carboxamido pyrazoline (Va-e) treated with DMSO/I2 to give 1-carboxamido pyrazole (V′a-e), 1-acetyl pyrazoline (VIa-e) treated with DMSO/I2 to give 1-acetyl pyrazole (VI′a-e), 1-benzoyl pyrazoline (VIIa-e) treated with DMSO/I2 to give 1-benzoyl pyrazole (VII′a-e) and 1-nitroso pyrazoline (VIIIa-e) treated with DMSO/I2 to give 1-nitroso pyrazole (VIII′a-e). Characterization and structural elucidation was carried out on the basis of melting points determination, analytical and spectral studies.