21178-99-4Relevant academic research and scientific papers
TBHP/Cu(OAc)2 mediated oxidation of pyrazolines: A convenient method for the preparation of pyrazoles
Kolla, Sai Teja,Somanaboina, Ramya,Bhimapaka, China Raju
supporting information, p. 1425 - 1432 (2021/02/27)
An efficient and simple oxidative protocol has been developed for the preparation of pyrazoles from pyrazolines mediated by TBHP/Cu(OAc)2 at room temperature. The present protocol has been successfully applied for the preparation of various pyrazole compounds from heterocyclic pyrazolines.
Iron-catalyzed aerobic oxidative aromatization of 1,3,5-trisubstituted pyrazolines
Ananthnag, Guddekoppa S.,Adhikari, Adithya,Balakrishna, Maravanji S.
supporting information, p. 240 - 243 (2013/12/04)
A simple and high yielding method for the synthesis of tri-substituted pyrazoles via iron(III) catalyzed aerobic oxidative aromatization of pyrazolines has been reported. The process demonstrates a variety of functional group tolerance.
PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions: One-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes
Liu, Pei,Pan, Ying-Ming,Xu, Yan-Li,Wang, Heng-Shan
supporting information; experimental part, p. 4696 - 4698 (2012/08/08)
A convenient one-pot Mannich-type-cyclization-oxidation tandem process has been developed for the synthesis of 1,3,5-trisubstituted pyrazoles derivatives from aldehydes, hydrazines and alkynes using p-toluenesulfonic acid monohydrate (PTSA) as a multifunctional catalyst. This method provides a flexible and rapid route to 1,3,5-trisubstituted pyrazoles.
Silica-supported 1,3-dichloro-5,5-dimethylhydantoin (DCH) as a useful reagent for microwave-assisted aromatization of 1,3,5-trisubstituted pyrazolines under solvent-free conditions
Azarifar, Davood,Nadimi, Elahe,Ghanbari, Mohammd Mehdi
experimental part, p. 447 - 450 (2012/02/01)
1,3,5-Trisubstituted pyrazolines are rapidly and conveniently oxidized to their corresponding pyrazoles by 1,3-dichloro-5,5-dimethylhydantoin (DCH) in solution and solvent-free conditions under microwave irradiation. The presence of silica gel as a suppor
Synthesis of 3,5-disubstituted pyrazoles and their derivatives
Ingle,Doshi,Raut,Kadu
experimental part, p. 1691 - 1698 (2012/06/15)
2-Acetylthiophene condenses with different aromatic aldehyde in ethanol in the presence of aqueous NaOH to give 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-one (Ia-e) which reacts with hydrazine hydrate in ethanol to give pyrazoline (IIa-e) and also treated with DMSO in presence of catalytic amount of iodine to give pyrazole (II′a-e) Similarly, 1-phenyl pyrazoline (IIIa-e) treated with DMSO/I2 to give 1-phenyl pyrazole(III′a- e), 1-(2,4-dinitro phenyl) pyrazoline (IVa-e) treated with DMSO/I2 to give 1-(2,4-dinitro phenyl) pyrazole(IV′a-e), 1-carboxamido pyrazoline (Va-e) treated with DMSO/I2 to give 1-carboxamido pyrazole (V′a-e), 1-acetyl pyrazoline (VIa-e) treated with DMSO/I2 to give 1-acetyl pyrazole (VI′a-e), 1-benzoyl pyrazoline (VIIa-e) treated with DMSO/I2 to give 1-benzoyl pyrazole (VII′a-e) and 1-nitroso pyrazoline (VIIIa-e) treated with DMSO/I2 to give 1-nitroso pyrazole (VIII′a-e). Characterization and structural elucidation was carried out on the basis of melting points determination, analytical and spectral studies.
Microwave-promoted aromatization of 1,3,5-trisubstituted 4,5-dihydro-ih-pyrazoles by calcium hypochlorite under solvent-free conditions
Azarifar, Davood,Gharshasbi, Azadeh
, p. 1209 - 1215 (2007/10/03)
An efficient microwave-promoted aromatization of 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazoles using calcium hypochlorite [Ca(OCl)2] has been reported. The reaction proceeds very fast to give pyrazoles in good yields on irradiation of a mixture
