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1-Ethyl-1,2,3,4-tetrahydroquinoline, with the CAS Number 635-46-1, is an organic compound belonging to the Quinolines and Isoquinolines, derivatives thereof. It is a clear, colorless liquid with a strong, unpleasant odor. 1-Ethyl-1,2,3,4-tetrahydroquinoline is primarily used in the synthesis of other chemical compounds and is valued for its reactivity and versatility in chemical and pharmaceutical research.

16768-69-7

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16768-69-7 Usage

Uses

Used in Chemical Synthesis:
1-Ethyl-1,2,3,4-tetrahydroquinoline is used as a synthetic intermediate for the production of various chemical compounds. Its reactivity and versatility make it a valuable component in the synthesis process.
Used in Pharmaceutical Research:
1-Ethyl-1,2,3,4-tetrahydroquinoline is used as a research compound in pharmaceutical studies. Its properties and reactivity contribute to the development of new drugs and therapeutic agents.
Used in Industrial Applications:
1-Ethyl-1,2,3,4-tetrahydroquinoline is used as a chemical component in various industrial applications. Its presence in the synthesis of other compounds makes it an essential part of the manufacturing process.
Safety Precautions:
Due to its potential flammability, 1-Ethyl-1,2,3,4-tetrahydroquinoline should be kept away from open flames or high heat. Appropriate safety measures must be taken when handling and storing 1-Ethyl-1,2,3,4-tetrahydroquinoline to prevent accidents. Additionally, it is crucial to avoid inhalation or contact with skin and eyes to minimize health risks.

Check Digit Verification of cas no

The CAS Registry Mumber 16768-69-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,6 and 8 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 16768-69:
(7*1)+(6*6)+(5*7)+(4*6)+(3*8)+(2*6)+(1*9)=147
147 % 10 = 7
So 16768-69-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H15N/c1-2-12-9-5-7-10-6-3-4-8-11(10)12/h3-4,6,8H,2,5,7,9H2,1H3

16768-69-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-ethyl-3,4-dihydro-2H-quinoline

1.2 Other means of identification

Product number -
Other names N-ethyl-1,2,3,4-tetrahydroquinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16768-69-7 SDS

16768-69-7Relevant academic research and scientific papers

Novel aza-BODIPY based small molecular NIR-II fluorophores for: In vivo imaging

Bai, Lei,Sun, Pengfei,Liu, Yi,Zhang, Hang,Hu, Wenbo,Zhang, Wansu,Liu, Zhipeng,Fan, Quli,Li, Lin,Huang, Wei

, p. 10920 - 10923 (2019)

The development of new NIR-II fluorophores, particularly those with facile syntheses, high fluorescence quantum yields, and stable and tunable photophysical properties, is challenging. Herein, we report a new class of small molecular NIR-II fluorophores based on aza-dipyrromethene boron difluoride (aza-BODIPY) dyes. We demonstrate promising photophysical properties of these dyes, such as large Stokes shift, superior photostability, and good fluorescence brightness as nanoparticles in aqueous solution. Because of these properties and high resolution and deep penetration NIR-II imaging ability, the aza-BODIPY based dyes show great potential as NIR-II imaging agents.

Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations

Liu, Shuyang,Tian, Miao,Bu, Xiubin,Tian, Hua,Yang, Xiaobo

, p. 7738 - 7744 (2021/05/07)

Photoactive two-dimensional covalent organic frameworks (2D-COFs) have become promising heterogenous photocatalysts in visible-light-driven organic transformations. Herein, a visible-light-driven selective aerobic oxidation of various small organic molecules by using 2D-COFs as the photocatalyst was developed. In this protocol, due to the remarkable photocatalytic capability of hydrazone-based 2D-COF-1 on molecular oxygen activation, a wide range of amides, quinolones, heterocyclic compounds, and sulfoxides were obtained with high efficiency and excellent functional group tolerance under very mild reaction conditions. Furthermore, benefiting from the inherent advantage of heterogenous photocatalysis, prominent sustainability and easy photocatalyst recyclability, a drug molecule (modafinil) and an oxidized mustard gas simulant (2-chloroethyl ethyl sulfoxide) were selectively and easily obtained in scale-up reactions. Mechanistic investigations were conducted using radical quenching experiments and in situ ESR spectroscopy, all corroborating the proposed role of 2D-COF-1 in photocatalytic cycle.

Sodium Triethylborohydride-Catalyzed Controlled Reduction of Unactivated Amides to Secondary or Tertiary Amines

Yao, Wubing,He, Lili,Han, Deman,Zhong, Aiguo

, (2019/11/14)

The first transition-metal-free catalytic protocol for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents has been established. By altering the hydrosilane and solvent, the new method enables the selective cleavage of unactivated C-O bonds in amides and allows the C-N bonds to selectively break via the deacylated cleavage. Overall, this novel process may offer a versatile alternative to current methodologies employing stoichiometric metal systems for the controlled reduction of carboxamides.

Sodium Triethylborohydride-Catalyzed Controlled Reduction of Unactivated Amides to Secondary or Tertiary Amines

Yao, Wubing,He, Lili,Han, Deman,Zhong, Aiguo

, p. 14627 - 14635 (2019/12/02)

The first transition-metal-free catalytic protocol for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents has been established. By altering the hydrosilane and solvent, the new method enables the selective cleavage of unactivated C-O bonds in amides and allows the C-N bonds to selectively break via the deacylated cleavage. Overall, this novel process may offer a versatile alternative to current methodologies employing stoichiometric metal systems for the controlled reduction of carboxamides.

B(C6F5)3-Catalyzed Deoxygenative Reduction of Amides to Amines with Ammonia Borane

Pan, Yixiao,Luo, Zhenli,Han, Jiahong,Xu, Xin,Chen, Changjun,Zhao, Haoqiang,Xu, Lijin,Fan, Qinghua,Xiao, Jianliang

supporting information, p. 2301 - 2308 (2019/01/30)

The first B(C6F5)3-catalyzed deoxygenative reduction of amides into the corresponding amines with readily accessible and stable ammonia borane (AB) as a reducing agent under mild reaction conditions is reported. This metal-free protocol provides facile access to a wide range of structurally diverse amine products in good to excellent yields, and various functional groups including those that are reduction-sensitive were well tolerated. This new method is also applicable to chiral amide substrates without erosion of the enantiomeric purity. The role of BF3 ? OEt2 co-catalyst in this reaction is to activate the amide carbonyl group via the in situ formation of an amide-boron adduct. (Figure presented.).

Ru-Catalyzed Deoxygenative Transfer Hydrogenation of Amides to Amines with Formic Acid/Triethylamine

Pan, Yixiao,Luo, Zhenli,Xu, Xin,Zhao, Haoqiang,Han, Jiahong,Xu, Lijin,Fan, Qinghua,Xiao, Jianliang

supporting information, p. 3800 - 3806 (2019/07/12)

A ruthenium(II)-catalyzed deoxygenative transfer hydrogenation of amides to amines using HCO2H/NEt3 as the reducing agent is reported for the first time. The catalyst system consisting of [Ru(2-methylallyl)2(COD)], 1,1,1-tris(diphenylphosphinomethyl) ethane (triphos) and Bis(trifluoromethane sulfonimide) (HNTf2) performed well for deoxygenative reduction of various secondary and tertiary amides into the corresponding amines in high yields with excellent selectivities, and exhibits high tolerance toward functional groups including those that are reduction-sensitive. The choice of hydrogen source and acid co-catalyst is critical for catalysis. Mechanistic studies suggest that the reductive amination of the in situ generated alcohol and amine via borrowing hydrogen is the dominant pathway. (Figure presented.).

Method for selective reducing reaction of tertiary aryl amide and borane

-

Paragraph 0085-0088, (2019/10/23)

The present invention relates to a method for a selective reducing reaction of a tertiary aryl amide and borane. A tertiary amine product is prepared by the reducing reaction of a tertiary aryl amidederivative and a cheap and easily available organoboron reagent under mild conditions under the convenient catalysis of a non-transition metal compound sodium triethylborohydride used as a catalyst for the first time. Compared with traditional methods, the method of the method generally has the advantages of wide universality of a substrate, low cost and easy availability of the catalyst, and simplicity in reaction operation. The selective reducing reaction of the tertiary aryl amide compound and the organoboron reagent under the catalysis of the transition metal catalyst is realized for the first time, and a brand new "green" reaction strategy is provided for the laboratory preparation or industrial production of tertiary arylamine products.

Method for efficiently preparing tetrahydroquinoline compound, and catalyst with acid or alkaline carrier supporting Ni metal

-

Paragraph 0023; 0025; 0026, (2018/11/27)

The invention relates to a method for efficiently preparing a tetrahydroquinoline compound, and a catalyst with an acid or alkaline carrier supporting Ni metal, and belongs to the field of biomass ethanol conversion. The invention also relates to an application of the co-catalyst with a metal active center and the solid acid or alkaline carrier in the synthesis of 1,2,3,4-tetrahydroquinoline, andbelongs to the technical field of biomass ethanol conversion. The catalyst consists of uniformly dispersed nickel nano particles and a nickel-aluminum (zirconium) composite oxide. The catalyst is prepared by in-situ topological transformation of nickel-containing hydrotalcite (NiAl-LDHs, NiAlZr-LDHs), and has the advantages that a strong interface interaction exists between the Ni nano particles and the carrier. When a reaction is carried out at the temperature of 125 DEG for 16 hours, and the yield of 1,2,3,4-tetrahydroquinoline by the catalysis of Ni-NiAl-LDO can reach 97%. When the reactionis carried out for 26 hours, the yield of 1,2,3,4-tetrahydroquinoline by the catalysis of Ni-NiAlZr-LDO can reach 95%.

Iridium-Catalyzed Direct Cyclization of Aromatic Amines with Diols

Minakawa, Maki,Watanabe, Kouichi,Toyoda, Satoru,Uozumi, Yasuhiro

, p. 2385 - 2389 (2018/11/23)

We developed an environmentally friendly iridium-catalyzed direct cyclization of aromatic amines with diols that generates the corresponding N-heterocyclic compounds with water as the sole by-product. Thus, under conditions of 165 °C for 18 hours, the direct cyclization of N -methylanilines with 1,3-propanediol by using an IrCl 3 catalyst with rac -BINAP as a ligand in mesitylene afforded the corresponding tetrahydroquinoline derivatives with yields ranging from 73 to 83%. Under similar reaction conditions, direct cyclization of anilines with 1,3-propanediol produced the corresponding tetrahydrobenzoquinolizine derivatives with yields ranging from 26 to 76%.

Novel nonmetal catalytic bidirectional selective reduction method of tertiary aromatic amide

-

Paragraph 0094; 0095; 0096; 0097, (2017/10/22)

The invention relates to a novel effective bidirectional selective environment-friendly method for hydrosilation reduction of tertiary aromatic amide and an organic silicon reagent. The method comprises the following steps: selecting a nonmetal catalytic system, and selectively preparing a secondary or tertiary organic amine compound by successively catalyzing tertiary aromatic amide and cheap PHMS or triethoxysilane under a mild condition. By adopting the method, the bidirectional selective reduction of the tertiary aromatic amide is realized by innovatively utilizing an electronic effect and steric hindrance difference of an organic silicon reagent at first time, so that a brand new strategy is provided for the reduction of amide and derivative of the amide, the defects of the traditional method that the substrate functional group is poor in compatibility, the production cost is high and the like can be overcome, and the application prospect of the amine compound prepared in industrial production or laboratory is promising.

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