1685-80-9

Usage

Uses

Used in the Synthesis of Fragrances and Flavors:
2,4-Dimethylcinnamic acid is used as a key intermediate in the synthesis of fragrances and flavors due to its unique aromatic properties. Its chemical structure allows for the creation of a wide range of scents and tastes, making it valuable in the perfumery and food industries.
Used in Pharmaceutical Synthesis:
As a member of the cinnamic acid family, 2,4-Dimethylcinnamic acid is utilized as a building block in the synthesis of various pharmaceuticals. Its versatile chemical structure enables the development of new drugs with potential therapeutic benefits.
Used in Chemical Research:
2,4-Dimethylcinnamic acid is employed as a research compound in the field of chemistry. Its unique structure and potential bioactive properties make it an interesting subject for studies aimed at understanding its chemical behavior and exploring its applications in various chemical processes.
Used in Material Science:
In the field of material science, 2,4-Dimethylcinnamic acid is used for the development of new materials with specific properties. Its chemical structure can be manipulated to create materials with tailored characteristics, such as improved stability or enhanced reactivity, for use in various applications.

InChI:InChI=1/C11H12O2/c1-8-3-4-10(9(2)7-8)5-6-11(12)13/h3-7H,1-2H3,(H,12,13)/b6-5+

Upstream product

• 141-82-2 malonic acid 
• 15764-16-6 2,4-dimethylbenzaldehyde 
• 7664-41-7 ammonia 
• 583-70-0 1-bromo-2,4-dimethylbenzene 
• 23617-71-2 2,4-dimethyl-benzoic acid methyl ester 
• 106-42-3 para-xylene 
• 95-68-1 2,4-Xylidine 
• 108-38-3 m-xylene 
• 16308-92-2 2,4-dimethylbenzyl alcohol 
• 611-01-8 2,4-dimethyl-benzoic acid 
• 89-74-7 2,4-dimethylacetophenone. 

Downstream Products

• 308336-33-6 5-(2-(2,4-Dimethylcinnamoylamino)ethyl)-2-methoxybenzenesulfonamide 
• 1811-85-4 3-(2,4-dimethylphenyl)propionic acid 
• 1685-81-0 4,6-dimethyl-2,3-dihydro-1H-inden-1-one 
• 54443-82-2 2,4-dimethyl-cinnamyl alcohol 
• 61052-15-1 (E)-ethyl 3-(2,4-dimethylphenyl)acrylate 
• 1685-82-1 4,6-dimethylindane 

Relevant academic research and scientific papers

Radical-Cation Vinylcyclopropane Rearrangements by TiO2Photocatalysis

Radical cation vinylcyclopropane rearrangements by TiO2 photocatalysis in lithium perchlorate/nitromethane solution are described. The reactions are triggered by oxidative single electron transfer, which is followed by immediate ring-opening of the cyclopropanes to generate distonic radical cations as unique reactive intermediates. This approach can also be applied to vinylcyclobutane, leading to the construction of six-membered rings. A stepwise mechanism via distonic radical cations is proposed based on preliminary mechanistic studies, which is supported by density functional theory calculations.

Chiral phosphoric acid catalyzed enantioselective annulation of acyclic enecarbamates to: In situ -generated ortho -quinone methides

The first organocatalytic asymmetric reaction of acyclic enecarbamates with o-quinone methides is disclosed. BINOL-based phosphoric acid catalysts were found to be suitable for the annulation reaction. With 10 mol% of the TRIP catalyst, high yields as well as excellent diastereo- and enantioselectivities are achieved for a variety of 2,3,4-trisubstituted chroman products.

5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES

The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I),wherein X represents CH2 or O; R1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, cyano, trifluoromethoxy and trifluoromethyl; R2 represents (C1-4)alkyl, (C1-4)alkoxy, (C2-4)alkenyl, halogen, cyano, hydroxymethyl, trifluoromethyl, C(O)NR5R6 or cyclopropyl; R3 represents (C1-4)alkyl, (C1-4)alkoxy-methyl or halogen; R4 represents (C1-4)alkyl; R5 represents hydrogen or (C1-4)alkyl; and R6 represents hydrogen or (C1-4)alkyl. The invention also relates to pharmaceutically acceptable salts of such compounds; and to the use of such compounds as medicaments; especially as orexin receptor antagonists.

Bicyclic cyclohexylamines and their use as nmda receptor antagonists

Described are bicycle-substituted cyclohexylamines of Formula (I) and their pharmaceutically acceptable salts thereof. The compounds are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, cerebral ischemia, cardiac arrest, stroke, and Parkinson's specification. disease. The substituents are defined in the specification.

Aromatic Spiranes XX [1]: Syntheses of Dimethylsubstituted 2-Carboxymethyl-indan-1-ones and Benzylchlorides as Synthones for Syntheses of di- to tetramethylsubstituted Spirobiindandiones

The isomeric dimethyl methylbenzoates 5, obtained from the bromides via Grignard reactions with dimethylcarbonate, were reduced with LiAlH4 to the hydroxymethyl derivatives 6. The latter were then transformed both to the benzylchlorides 7 (with SOCl2) and to the aldehydes 8 (with pyridinium chlorochromate). Knoevenagel-Doebner reaction of 8 afforded the acrylic acids 9 which (after hydrogenation to 11) were cyclized to the desired indanones 12 with polyphosphoric acid. On the other hand, 12c and 12e were prepared from dimethyl 3-chloropropiophenone (14) by warming with sulfuric acid. After NaH-catalyzed reaction with dimethylcarbonate, the indanones 12 gave the ketoesters 15 which then could be hydrogenated to the indanes 16. All reactions proceeded with satisfactory to excellent yields (60-90%).